Slc23a1 solute carrier family 23 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc23a1provided by RGD
Official Full Name: solute carrier family 23 member 1provided by RGD
Primary source: RGD:619875
See related: Ensembl:ENSRNOG00000061695 AllianceGenome:RGD:619875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SVCT1
Summary: Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Located in basal plasma membrane; brush border; and cytoplasm. Orthologous to human SLC23A1 (solute carrier family 23 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 264.2), Liver (RPKM 172.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (27490549..27504563, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (27214940..27230564, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (28413910..28428133, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

metabolic/oxidative stress in the liver induce different responses in the expression of ascorbic acid transporters SVCT1 and SVCT2 in intrahepatic and extrahepatic tissues, which may affect the overall bioavailability and cellular uptake of this vitamin
Title: Liver metabolic/oxidative stress induces hepatic and extrahepatic changes in the expression of the vitamin C transporters SVCT1 and SVCT2.
glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells.
Title: Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found.
Title: Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases.
SVCT1 immunoreactivity was observed in the brush border of proximal straight tubules in the medullary ray of renal cortex and the outer stripe of outer medulla, while SVCT2 was not localized in any region of the kidney.
Title: Immunohistochemical localization of sodium-dependent L-ascorbic acid transporter 1 protein in rat kidney.
SVCT1 declines 45% with age
Title: Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.
inhibited by flavonoids, an intestinal transporter for vitamin c
Title: Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137333 (e-PCR)
- UniSTS:219421

RH129257 (e-PCR)
- UniSTS:212564

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-ascorbate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbate:sodium symporter activity	IEA Inferred from Electronic Annotation more info
NOT enables L-ascorbate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables L-ascorbate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables L-ascorbate:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-ascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-ascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid transmembrane transport	IEA Inferred from Electronic Annotation more info
NOT involved_in L-ascorbic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in dehydroascorbic acid transport	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in dehydroascorbic acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in urate transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 23 member 1

Names: Na(+)/L-ascorbic acid transporter 1; sodium-coupled ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; solute carrier family 23 (ascorbic acid transporter), member 1; solute carrier family 23 (nucleobase transporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017315.2 → NP_059011.1 solute carrier family 23 member 1

See identical proteins and their annotated locations for NP_059011.1

Status: PROVISIONAL

Source sequence(s)

BC078851

UniProtKB/Swiss-Prot

Q9WTW7

UniProtKB/TrEMBL

A6J2Y7

Conserved Domains (1) summary

pfam00860
Location:52 → 479

Xan_ur_permease; Permease family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

27490549..27504563 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254602.5 → XP_006254664.1 solute carrier family 23 member 1 isoform X1

UniProtKB/TrEMBL

A0A8L2R5A1

Related

ENSRNOP00000072205.2

Conserved Domains (2) summary

pfam00860
Location:114 → 541

Xan_ur_permease; Permease family

cl23746
Location:97 → 551

HCO3_cotransp; HCO3- transporter family