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    Slc26a2 solute carrier family 26 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117267, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc26a2provided by RGD
    Official Full Name
    solute carrier family 26 member 2provided by RGD
    Primary source
    RGD:620622
    See related
    Ensembl:ENSRNOG00000018082 AllianceGenome:RGD:620622
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dtdst
    Summary
    Enables sulfate transmembrane transporter activity. Involved in ossification and sulfate transport. Located in apical plasma membrane and microvillus membrane. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 95.5), Thymus (RPKM 57.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc26a2 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56918662..56937032, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54648276..54666627, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56518999..56534539, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 1 receptor Neighboring gene HMG-box containing 3 Neighboring gene phosphodiesterase 6A Neighboring gene uncharacterized LOC120098169 Neighboring gene PPARG coactivator 1 beta Neighboring gene microRNA 3557 Neighboring gene microRNA 378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SLC26A2 disease spectrum in Sweden - high frequency of recessive multiple epiphyseal dysplasia (rMED). Mäkitie O, et al. Clin Genet, 2015 Mar. PMID 24598000
    2. Protein localization of SLC26A2 (DTDST) in rat kidney. Chapman JM, et al. Histochem Cell Biol, 2010 May. PMID 20369363
    3. Identification of the Finnish founder mutation for diastrophic dysplasia (DTD). Hästbacka J, et al. Eur J Hum Genet, 1999 Sep. PMID 10482955
    4. Clinical and molecular characterization of Diastrophic Dysplasia in the Portuguese population. Barbosa M, et al. Clin Genet, 2011 Dec. PMID 21155763
    5. Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis. Lamb R, et al. Arthritis Rheum, 2007 Apr. PMID 17393463

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chondrocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondrocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ossification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxalate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sulfate transporter
    Names
    diastrophic dysplasia protein homolog
    solute carrier family 26 (anion exchanger), member 2
    solute carrier family 26 (sulfate transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057127.1 → NP_476468.1  sulfate transporter

      See identical proteins and their annotated locations for NP_476468.1

      Status: PROVISIONAL

      Source sequence(s)
      D82883
      UniProtKB/Swiss-Prot
      O70531
      UniProtKB/TrEMBL
      A6IXG4
      Related
      ENSRNOP00000024374.1, ENSRNOT00000024374.3
      Conserved Domains (1) summary
      TIGR00815
      Location:94 → 715
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56918662..56937032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254788.4 → XP_006254850.1  sulfate transporter isoform X1

      See identical proteins and their annotated locations for XP_006254850.1

      UniProtKB/Swiss-Prot
      O70531
      UniProtKB/TrEMBL
      A6IXG4
      Conserved Domains (1) summary
      TIGR00815
      Location:94 → 715
      sulP; high affinity sulphate transporter 1

    2. XM_039096558.1 → XP_038952486.1  sulfate transporter isoform X2

      Conserved Domains (1) summary
      TIGR00815
      Location:1 → 480
      sulP; high affinity sulphate transporter 1

    3. XM_039096557.1 → XP_038952485.1  sulfate transporter isoform X2

      Conserved Domains (1) summary
      TIGR00815
      Location:1 → 480
      sulP; high affinity sulphate transporter 1

    4. XM_006254787.3 → XP_006254849.1  sulfate transporter isoform X1

      See identical proteins and their annotated locations for XP_006254849.1

      UniProtKB/Swiss-Prot
      O70531
      UniProtKB/TrEMBL
      A6IXG4
      Conserved Domains (1) summary
      TIGR00815
      Location:94 → 715
      sulP; high affinity sulphate transporter 1

    5. XM_063277079.1 → XP_063133149.1  sulfate transporter isoform X1

      UniProtKB/Swiss-Prot
      O70531
      UniProtKB/TrEMBL
      A6IXG4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70531.1 GenPept UniProtKB/Swiss-Prot:O70531

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