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    Iars1 isoleucyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306804, updated on 13-Apr-2024

    Summary

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    Symbol
    Iars1provided by RGD
    Full Name
    isoleucyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:621022
    See related
    Ensembl:ENSRNOG00000014616 AllianceGenome:RGD:621022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Iars; Iarsl
    Summary
    Predicted to enable GTPase binding activity and isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 158.2), Muscle (RPKM 135.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iars1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15147357..15193716, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (14940919..14987277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15356016..15402680, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene SPATA31 subfamily E, member 1 like 2 Neighboring gene uncharacterized LOC134482685 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P Neighboring gene osteoglycin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. Shiba K, et al. Proc Natl Acad Sci U S A, 1994 Aug 2. PMID 8052601, Free PMC Article
    2. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, et al. Arterioscler Thromb Vasc Biol, 1999 Nov. PMID 10559001
    3. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Han JM, et al. Cell, 2012 Apr 13. PMID 22424946
    4. Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells. Kaminska M, et al. J Biol Chem, 2009 May 15. PMID 19289464, Free PMC Article
    5. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. Kaminska M, et al. J Biol Chem, 2009 Mar 6. PMID 19131329

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isoleucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within isoleucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    Names
    isoleucine--tRNA ligase, cytoplasmic-like
    isoleucine-tRNA synthetase
    isoleucyl tRNA synthetase
    isoleucyl-tRNA synthetase, cytoplasmic
    NP_001094042.1
    XP_006253768.1
    XP_008769755.1
    XP_063132424.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100572.1 → NP_001094042.1  isoleucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001094042.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A1W2Q6K1, A6J6V4, F1LS86
      Related
      ENSRNOP00000019862.6, ENSRNOT00000019862.7
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 → 1070
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15147357..15193716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253706.5 → XP_006253768.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006253768.1

      UniProtKB/TrEMBL
      A0A1W2Q6K1, A6J6V4, F1LS86
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 → 1070
      PLN02882; aminoacyl-tRNA ligase

    2. XM_008771533.4 → XP_008769755.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_008769755.1

      UniProtKB/TrEMBL
      A0A1W2Q6K1, A6J6V4, F1LS86
      Related
      ENSRNOP00000085677.1
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 → 1070
      PLN02882; aminoacyl-tRNA ligase

    3. XM_063276354.1 → XP_063132424.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A6J6V4, F1LS86
    Nucleotide Protein Strain
    Heading Accession and Version

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