Rassf1 Ras association domain family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rassf1provided by RGD
Official Full Name: Ras association domain family member 1provided by RGD
Primary source: RGD:1359383
See related: Ensembl:ENSRNOG00000021548 AllianceGenome:RGD:1359383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; protein N-terminus binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to be located in microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Human ortholog(s) of this gene implicated in breast cancer; reproductive organ cancer (multiple); transitional cell carcinoma; and urinary system cancer (multiple). Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 104.1), Thymus (RPKM 75.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117103665..117114805)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108225023..108236164)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116307149..116318289)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RASSF1 promotes cardiomyocyte apoptosis after acute myocardial infarction and is regulated by miR-125b.
Title: RASSF1 promotes cardiomyocyte apoptosis after acute myocardial infarction and is regulated by miR-125b.
The results suggest a previously unknown mechanism of HDAC6 inactivation of RASSF1A controls cardiac fibroblast proliferation and fibrosis.
Title: HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression.
DNMT3A and RASSF1A may serve as a new mechanism for cardiac fibrosis.
Title: DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.
Apoptotic Ras effector molecules RASSF1 and NORE1 play important role in NGF reduction and TNF-alpha-related pancreatic beta cell apoptosis in hyperglycemic rats.
Title: Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats.
These findings suggest that loss of function or decrease of RAR-beta2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5' region of these genes, are related with nickel exposure.
Title: Methylation of RAR-β2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats.
Transcriptional repression of Rassf1a in mammary glands during early carcinogenesis was associated with an increase in trimethylation of histones H3 lysine 9 & H3 lysine 27 &de novo CpG island methylation & at the Rassf1a promoter & first exon.
Title: Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141417 (e-PCR)
- UniSTS:223411

RH136990 (e-PCR)
- UniSTS:219079

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras association domain-containing protein 1

Names: Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007754.1 → NP_001007755.1 ras association domain-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_001007755.1

Status: PROVISIONAL

Source sequence(s)

BC079237

UniProtKB/TrEMBL

A6I2X9, F7F8L4, Q68FW0

Related

ENSRNOP00000034233.3, ENSRNOT00000037363.5

Conserved Domains (2) summary

cd17218
Location:60 → 216

RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)

pfam16517
Location:226 → 264

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
NM_001037555.2 → NP_001032644.1 ras association domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_001032644.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A9K3Y7P1, F1M9A9, Q5FAQ9

Related

ENSRNOP00000030024.4, ENSRNOT00000037375.7

Conserved Domains (3) summary

cd17218
Location:130 → 286

RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)

pfam16517
Location:296 → 334

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

cd20885
Location:49 → 102

C1_RASSF1; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117103665..117114805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081797.2 → XP_038937725.1 ras association domain-containing protein 1 isoform X1

Conserved Domains (2) summary

cd17218
Location:27 → 183

RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)

pfam16517
Location:193 → 231

Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain