Nav2 neuron navigator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nav2provided by RGD
Official Full Name: neuron navigator 2provided by RGD
Primary source: RGD:619778
See related: Ensembl:ENSRNOG00000014530 AllianceGenome:RGD:619778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rainb1
Summary: Predicted to enable 3'-5' DNA helicase activity and heparin binding activity. Involved in nervous system development. Predicted to be located in interstitial matrix and nucleoplasm. Orthologous to human NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 118.4), Lung (RPKM 84.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (107799968..108458546)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (98957629..99322339)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (104575765..104941554)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos
Title: A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141496 (e-PCR)
- UniSTS:223490

BI288607 (e-PCR)
- UniSTS:246278

36.MMHAP29FRD12.seq (e-PCR)
- UniSTS:124179

UniSTS:498520 (e-PCR)
- UniSTS:498520

Nav2 (e-PCR), detects polymorphism
- UniSTS:498520

RH135248 (e-PCR)
- UniSTS:218525

BQ195500 (e-PCR)
- UniSTS:260518

D1Rat465 (e-PCR), detects polymorphism
- UniSTS:227247

RH138789 (e-PCR)
- UniSTS:220876

D1Got99 (e-PCR)
- UniSTS:112355

D1Rat102 (e-PCR)
- UniSTS:118512

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in cerebellar cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glossopharyngeal nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within optic nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by baroreceptor feedback	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vagus nerve development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in interstitial matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuron navigator 2

Names: retinoic acid inducible in neuroblastoma cells 1

NP_612538.1

EC 3.6.1.1

XP_017444230.1

EC 3.6.1.1

XP_063134070.1

EC 3.6.1.1

XP_063134105.1

EC 3.6.1.1

XP_063134130.1

EC 3.6.1.1

XP_063134159.1

EC 3.6.1.1

XP_063134191.1

EC 3.6.1.1

XP_063134221.1

EC 3.6.1.1

XP_063134246.1

EC 3.6.1.1

XP_063134274.1

EC 3.6.1.1

XP_063134333.1

EC 3.6.1.1

XP_063134353.1

EC 3.6.1.1

XP_063134370.1

EC 3.6.1.1

XP_063134395.1

EC 3.6.1.1

XP_063134477.1

EC 3.6.1.1

XP_063134528.1

EC 3.6.1.1

XP_063134552.1

EC 3.6.1.1

XP_063134601.1

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138529.1 → NP_612538.1 neuron navigator 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZQM9

Related

ENSRNOP00000074453.2, ENSRNOT00000078477.2

Conserved Domains (4) summary

smart00382
Location:2087 → 2195

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:86 → 187

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam13401
Location:2090 → 2177

AAA_22; AAA domain

pfam15898
Location:1844 → 1896

PRKG1_interact; cGMP-dependent protein kinase interacting domain