Uox urate oxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uoxprovided by RGD
Official Full Name: urate oxidaseprovided by RGD
Primary source: RGD:621369
See related: Ensembl:ENSRNOG00000016339 AllianceGenome:RGD:621369
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Uri; Uri2; UOX-2
Summary: Enables urate oxidase activity. Involved in urate catabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3195.8) See more
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Genomic context

Location:: 2q44

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (238147130..238183320)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (235486867..235523053)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (252452282..252488497)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency.
Title: Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency.
Uricase deficiency causes mild and multiple organ injuries in rats.
Title: Uricase deficiency causes mild and multiple organ injuries in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

UOX (e-PCR)
- UniSTS:264969

AI169989 (e-PCR)
- UniSTS:250452

RH136937 (e-PCR)
- UniSTS:219026

d2mgh13 (e-PCR)
- UniSTS:121588

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables urate oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables urate oxidase activity	IEA Inferred from Electronic Annotation more info
enables urate oxidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in AMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in IMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in adenosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in allantoin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dGMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyadenosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyguanosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in deoxyinosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in guanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hypoxanthine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in inosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleobase catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in urate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xanthine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in peroxisomal matrix	TAS Traceable Author Statement more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uricase

Names: urate oxidase 2

NP_446220.1

EC 1.7.3.3

XP_006233512.1

EC 1.7.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053768.2 → NP_446220.1 uricase

See identical proteins and their annotated locations for NP_446220.1

Status: PROVISIONAL

Source sequence(s)

M24396

UniProtKB/Swiss-Prot

P09118

UniProtKB/TrEMBL

A6HWE4

Related

ENSRNOP00000088332.1, ENSRNOT00000102853.1

Conserved Domains (2) summary

cd00445
Location:20 → 297

Uricase; Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the ...

TIGR03383
Location:15 → 297

urate_oxi; urate oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

238147130..238183320

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233450.4 → XP_006233512.1 uricase isoform X1

UniProtKB/Swiss-Prot

P09118

UniProtKB/TrEMBL

A6HWE4

Related

ENSRNOP00000021970.3

Conserved Domains (2) summary

cd00445
Location:13 → 290

Uricase; Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the ...

TIGR03383
Location:8 → 290

urate_oxi; urate oxidase