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    Rpl19 ribosomal protein L19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81767, updated on 6-Jun-2024

    Summary

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    Symbol
    Rpl19provided by RGD
    Full Name
    ribosomal protein L19provided by RGD
    Primary source
    RGD:621183
    See related
    Ensembl:ENSRNOG00000004741 AllianceGenome:RGD:621183
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 5.8S rRNA binding activity and large ribosomal subunit rRNA binding activity. Involved in liver regeneration. Part of cytosolic large ribosomal subunit. Orthologous to human RPL19 (ribosomal protein L19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 3543.9), Spleen (RPKM 3420.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl19 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83514509..83522352)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83022503..83026030)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85978691..85981979)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480866 Neighboring gene transfer RNA cysteine (anticodon GCA) 37 Neighboring gene ADP-ribosylation factor like GTPase 5C Neighboring gene calcium voltage-gated channel auxiliary subunit beta 1 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene uncharacterized LOC102548674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region. Davies B, et al. Genomics, 1995 Jan 20. PMID 7789970
    2. The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein. Chan YL, et al. J Biol Chem, 1987 Jan 25. PMID 3542997
    3. A strategy to detect and isolate an intron-containing gene in the presence of multiple processed pseudogenes. Davies B, et al. Proc Natl Acad Sci U S A, 1989 Sep. PMID 2771953, Free PMC Article
    4. Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1979 Sep 10. PMID 468846
    5. Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure. Prins GS, et al. Endocrinology, 2002 Sep. PMID 12193579

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5.8S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables large ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL19
    Names
    60S ribosomal protein L19
    60S ribosomal protein L19-like
    NP_112365.1
    XP_038942866.1
    XP_038942867.1
    XP_063126021.1
    XP_063126022.1
    XP_063126023.1
    XP_063126024.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031103.1 → NP_112365.1  large ribosomal subunit protein eL19

      See identical proteins and their annotated locations for NP_112365.1

      Status: PROVISIONAL

      Source sequence(s)
      X82202
      UniProtKB/Swiss-Prot
      P84100
      UniProtKB/TrEMBL
      A0A8I6G776, A6HIP8
      Related
      ENSRNOP00000006359.4, ENSRNOT00000006359.6
      Conserved Domains (1) summary
      cd01417
      Location:4 → 167
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83514509..83522352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269954.1 → XP_063126024.1  large ribosomal subunit protein eL19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G776

    2. XM_063269952.1 → XP_063126022.1  large ribosomal subunit protein eL19 isoform X1

      UniProtKB/Swiss-Prot
      P84100
      UniProtKB/TrEMBL
      A0A8I6G776, A6HIP8

    3. XM_063269953.1 → XP_063126023.1  large ribosomal subunit protein eL19 isoform X1

      UniProtKB/Swiss-Prot
      P84100
      UniProtKB/TrEMBL
      A0A8I6G776, A6HIP8

    4. XM_063269951.1 → XP_063126021.1  large ribosomal subunit protein eL19 isoform X1

      UniProtKB/Swiss-Prot
      P84100
      UniProtKB/TrEMBL
      A0A8I6G776, A6HIP8

    5. XM_039086938.2 → XP_038942866.1  large ribosomal subunit protein eL19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G776
      Conserved Domains (1) summary
      cd01417
      Location:2 → 165
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    6. XM_039086939.2 → XP_038942867.1  large ribosomal subunit protein eL19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G776
      Related
      ENSRNOP00000080853.1
      Conserved Domains (1) summary
      cd01417
      Location:2 → 165
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84100.1 GenPept UniProtKB/Swiss-Prot:P84100

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