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    Doc2a double C2 domain alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65031, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Doc2aprovided by RGD
    Official Full Name
    double C2 domain alphaprovided by RGD
    Primary source
    RGD:620518
    See related
    Ensembl:ENSRNOG00000019920 AllianceGenome:RGD:620518
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Involved in synaptic vesicle exocytosis. Located in lysosome. Is extrinsic component of synaptic vesicle membrane. Orthologous to human DOC2A (double C2 domain alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 76.8), Adrenal (RPKM 37.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Doc2a in Genome Data Viewer
    Location:
    1q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190887306..190893057)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181457415..181462528)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198282828..198288611)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TLC domain containing 3B Neighboring gene uncharacterized LOC134483857 Neighboring gene similar to human chromosome 16 open reading frame 92 Neighboring gene INO80 complex subunit E Neighboring gene HIRA interacting protein 3 Neighboring gene TAO kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development. Korteweg N, et al. Eur J Neurosci, 2000 Jan. PMID 10651871
    2. Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain. Naito A, et al. Brain Res Mol Brain Res, 1997 Mar. PMID 9073161
    3. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Verhage M, et al. Neuron, 1997 Mar. PMID 9115738
    4. Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Yao J, et al. Cell, 2011 Oct 28. PMID 22036572, Free PMC Article
    5. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. Higashio H, et al. J Immunol, 2008 Apr 1. PMID 18354201

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium-dependent activation of synaptic vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-dependent activation of synaptic vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spontaneous neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spontaneous neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle exocytosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    double C2-like domain-containing protein alpha
    Names
    doc2-alpha
    double C2, alpha
    double C2-like domains, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022937.3 → NP_075226.1  double C2-like domain-containing protein alpha

      See identical proteins and their annotated locations for NP_075226.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Related
      ENSRNOP00000027022.1, ENSRNOT00000027022.5
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190887306..190893057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272851.1 → XP_063128921.1  double C2-like domain-containing protein alpha isoform X1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0

    2. XM_006230335.5 → XP_006230397.1  double C2-like domain-containing protein alpha isoform X1

      See identical proteins and their annotated locations for XP_006230397.1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    3. XM_006230339.5 → XP_006230401.1  double C2-like domain-containing protein alpha isoform X1

      See identical proteins and their annotated locations for XP_006230401.1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    4. XM_006230337.5 → XP_006230399.1  double C2-like domain-containing protein alpha isoform X1

      See identical proteins and their annotated locations for XP_006230399.1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    5. XM_006230340.3 → XP_006230402.1  double C2-like domain-containing protein alpha isoform X1

      See identical proteins and their annotated locations for XP_006230402.1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    6. XM_006230336.3 → XP_006230398.1  double C2-like domain-containing protein alpha isoform X1

      See identical proteins and their annotated locations for XP_006230398.1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    7. XM_039089802.2 → XP_038945730.1  double C2-like domain-containing protein alpha isoform X1

      UniProtKB/Swiss-Prot
      P70611
      UniProtKB/TrEMBL
      A6I9G0
      Conserved Domains (2) summary
      cd04035
      Location:93 → 216
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:257 → 389
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70611.1 GenPept UniProtKB/Swiss-Prot:P70611

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