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    Pex3 peroxisomal biogenesis factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 56535, updated on 12-May-2024

    Summary

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    Official Symbol
    Pex3provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 3provided by MGI
    Primary source
    MGI:MGI:1929646
    See related
    Ensembl:ENSMUSG00000019809 AllianceGenome:MGI:1929646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700014F15Rik; 2810027F19Rik; 2900010N04Rik
    Summary
    Predicted to enable lipid binding activity and protein-macromolecule adaptor activity. Predicted to be involved in peroxisome membrane biogenesis and protein import into peroxisome membrane. Predicted to be located in several cellular components, including endoplasmic reticulum; nucleoplasm; and peroxisomal membrane. Predicted to be integral component of plasma membrane. Predicted to be part of protein-lipid complex. Predicted to be integral component of peroxisomal membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.6), bladder adult (RPKM 9.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pex3 in Genome Data Viewer
    Location:
    10 A2; 10 4.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13399586..13428886, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13523842..13553142, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 2 Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene androgen-induced 1 Neighboring gene predicted gene, 53613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Muntau AC, et al. Biol Chem, 2000 Apr. PMID 10839463
    2. The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear. Kochaj RM, et al. Cells, 2022 Oct 13. PMID 36291074, Free PMC Article
    3. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
    4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear.
      Title: The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-lipid complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal biogenesis factor 3
    Names
    peroxin-3
    peroxisomal assembly protein 3
    peroxisomal assembly protein PEX3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164195.1 → NP_001157667.1  peroxisomal biogenesis factor 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC153979, AK005978, AV256241
      Consensus CDS
      CCDS48503.1
      UniProtKB/TrEMBL
      E9QA46, Q8C6F0
      Related
      ENSMUSP00000128512.2, ENSMUST00000170376.8
      Conserved Domains (1) summary
      pfam04882
      Location:11 → 345
      Peroxin-3; Peroxin-3

    2. NM_001347361.1 → NP_001334290.1  peroxisomal biogenesis factor 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC153979, AK005315, AK013522
      Consensus CDS
      CCDS83681.1
      UniProtKB/TrEMBL
      D3Z6X3, D3Z6X4
      Related
      ENSMUSP00000101178.2, ENSMUST00000105539.2

    3. NM_019961.3 → NP_064345.1  peroxisomal biogenesis factor 3 isoform 1

      See identical proteins and their annotated locations for NP_064345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC153979, AK146934, CJ299039
      Consensus CDS
      CCDS23702.1
      UniProtKB/Swiss-Prot
      Q9QXY9
      UniProtKB/TrEMBL
      Q3UIG2, Q8C6F0
      Related
      ENSMUSP00000019945.9, ENSMUST00000019945.15
      Conserved Domains (1) summary
      pfam04882
      Location:11 → 361
      Peroxin-3; Peroxin-3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      13399586..13428886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXY9.1 GenPept UniProtKB/Swiss-Prot:Q9QXY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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