Amer2 APC membrane recruitment 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amer2provided by MGI
Official Full Name: APC membrane recruitment 2provided by MGI
Primary source: MGI:MGI:1919375
See related: Ensembl:ENSMUSG00000021986 AllianceGenome:MGI:1919375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam123a; 2600011E07Rik
Summary: Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human AMER2 (APC membrane recruitment protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 8.0), whole brain E14.5 (RPKM 7.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 31.62 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (60615141..60625642)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (60373288..60388197)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fam123a (e-PCR), detects polymorphism
- UniSTS:531047

BB253837 (e-PCR)
- UniSTS:209040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: APC membrane recruitment protein 2

Names: family with sequence similarity 123, member A; protein FAM123A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164705.2 → NP_001158177.2 APC membrane recruitment protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC166113

Consensus CDS

CCDS88682.1

UniProtKB/TrEMBL

A0A0R4J030

Related

ENSMUSP00000153031.3, ENSMUST00000225247.3

Conserved Domains (1) summary

pfam09422
Location:94 → 463

WTX; WTX protein
NM_001368677.1 → NP_001355606.1 APC membrane recruitment protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC166113

UniProtKB/TrEMBL

A0A0R4J030

Conserved Domains (1) summary

pfam09422
Location:94 → 532

WTX; WTX protein
NM_028113.4 → NP_082389.2 APC membrane recruitment protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC166113

Consensus CDS

CCDS27177.2

UniProtKB/Swiss-Prot

Q7TNC5, Q8CCJ4, Q8K0U9, Q9D0Q2

UniProtKB/TrEMBL

A0A0R4J030

Related

ENSMUSP00000022561.8, ENSMUST00000022561.9

Conserved Domains (1) summary

pfam09422
Location:94 → 589

WTX; WTX protein