Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabra3provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit alpha 3provided by RGD
Primary source: RGD:2648
See related: Ensembl:ENSRNOG00000056558 AllianceGenome:RGD:2648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA-A receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in chemical synaptic transmission. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 101.8) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (155301979..155543870, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (150244745..150501566, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (152414332..152642607, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain alpha3 and gamma1 Subunits and Present Differential Functional and Pharmacological Properties.
Title: GABA(A) Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties.
Sp4 functionally regulates the transcription of Gabra1 (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA alpha3) subunit genes.
Title: Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons.
presence of alpha2 and alpha3 subunits during early development might make them more amenable to becoming sensitized by environmental stressors, whereas the relative paucity of alpha1 subunits at this age might limit the sensitization of this subunit.
Title: Short- and long-term effects of juvenile stressor exposure on the expression of GABAA receptor subunits in rats.
clustering of GABA(A)R alpha2, alpha3, and GlyRs by gephyrin is mediated by distinct mechanisms at mixed glycinergic/GABAergic synapses.
Title: Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin.
Results describe the differential cellular distribution of alpha1, alpha2 and alpha3 GABA(A) receptor subunits in relation to striatopallidal (Str-GP) and pallidopallidal (GP-GP) synapses.
Title: Differential localization of GABA(A) receptor subunits in relation to rat striatopallidal and pallidopallidal synapses.
Our findings suggest that various combinations of GABA(A) alpha3-, theta- and epsilon-subunits may be assembled at a regional and developmental level in the brain.
Title: Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord.
localized changes in GABA(A)R expression acting at highly specific points in the interconnected thalamocortical network lie at the heart of idiopathic generalized epilepsy
Title: Reticular nucleus-specific changes in alpha3 subunit protein at GABA synapses in genetically epilepsy-prone rats.
These data demonstrate that the modulation of breathing via GABA(A) receptor activation will be determined by the overall balance of negative and positive neurosteroid modulators within respiratory nuclei.
Title: Neurosteroid modulation of respiratory rhythm in rats during the perinatal period.
a domain of four amino acids within the subunit mediates the distinct sensitivities to GABA;identified motifs contribute to a structure involved in the transduction of the binding signal rather than to the binding itself
Title: Four amino acids in the alpha subunits determine the gamma-aminobutyric acid sensitivities of GABAA receptor subtypes.
Developmental trends of subunits alpha1 and alpha3 intersected at P12. Switch in alpha3 and alpha1 during development may mediate different functional properties of GABA transmission.
Title: Developmental changes in the expression of GABAA receptor subunits alpha1, alpha2, and alpha3 in the rat pre-Botzinger complex.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Gabra3 (e-PCR), detects polymorphism
- UniSTS:525649

AU048027 (e-PCR)
- UniSTS:109945

Gabra3 (e-PCR), detects polymorphism
- UniSTS:496043

DXWox31 (e-PCR)
- UniSTS:517817

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-A receptor activity	TAS Traceable Author Statement more info	PubMed
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-gated chloride ion channel activity	IEA Inferred from Electronic Annotation more info
enables GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit alpha-3

Names: GABA(A) receptor subunit alpha-3; GABA-A receptor alpha-3 subunit; GABAAR subunit alpha-3; Gamma-animobutyric acid (GABA) A receptor, alpha 3; gamma-aminobutyric acid (GABA) A receptor, alpha 3; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3; gamma-aminobutyric acid type A receptor alpha3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017069.3 → NP_058765.3 gamma-aminobutyric acid receptor subunit alpha-3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

F1LNZ5, P20236

UniProtKB/TrEMBL

A0A8L2UPR9

Related

ENSRNOP00000070043.2, ENSRNOT00000085037.2

Conserved Domains (2) summary

cd19036
Location:75 → 274

LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)

cl42365
Location:69 → 479

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

155301979..155543870 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601916.3 → XP_017457405.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform X1

UniProtKB/Swiss-Prot

F1LNZ5, P20236

UniProtKB/TrEMBL

A0A8L2UPR9

Conserved Domains (2) summary

cd19036
Location:75 → 274

LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)

cl42365
Location:69 → 479

LIC; Cation transporter family protein