Dpys dihydropyrimidinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dpysprovided by RGD
Official Full Name: dihydropyrimidinaseprovided by RGD
Primary source: RGD:68376
See related: Ensembl:ENSRNOG00000004298 AllianceGenome:RGD:68376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DHP
Summary: Enables several functions, including dihydropyrimidinase activity; pyrimidine nucleobase binding activity; and zinc ion binding activity. Involved in beta-alanine metabolic process; thymine catabolic process; and uracil catabolic process. Located in cytosol. Part of protein-containing complex. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1117.6) and Kidney (RPKM 315.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (72707566..72814183, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (70822648..70929255, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (78769918..78847941, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydropyrimidinase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydropyrimidinase activity	IEA Inferred from Electronic Annotation more info
enables dihydropyrimidinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables thymine binding	IDA Inferred from Direct Assay more info	PubMed
enables uracil binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in CMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in CMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in UMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in UMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in beta-alanine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dCMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dCMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dUMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dUMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase catabolic process	ISO Inferred from Sequence Orthology more info
involved_in thymine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in uracil catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in uracil catabolic process	IEA Inferred from Electronic Annotation more info
involved_in uracil catabolic process	ISO Inferred from Sequence Orthology more info
involved_in uracil metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dihydropyrimidinase

Names: DHPase; dihydropyrimidine amidohydrolase; hydantoinase

NP_113893.2

EC 3.5.2.2

XP_038935787.1

EC 3.5.2.2

XP_038935789.1

EC 3.5.2.2

XP_038935790.1

EC 3.5.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031705.2 → NP_113893.2 dihydropyrimidinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q63150, Q642F0

UniProtKB/TrEMBL

A0A8I6AEZ1, A6HR83

Related

ENSRNOP00000006004.1, ENSRNOT00000006004.4

Conserved Domains (1) summary

cd01314
Location:7 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

72707566..72814183 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079862.2 → XP_038935790.1 dihydropyrimidinase isoform X2

UniProtKB/TrEMBL

A0A8I6AEZ1

Related

ENSRNOP00000093000.1

Conserved Domains (1) summary

cd01314
Location:7 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
XM_039079861.2 → XP_038935789.1 dihydropyrimidinase isoform X1

UniProtKB/Swiss-Prot

Q63150, Q642F0

UniProtKB/TrEMBL

A0A8I6AEZ1, A6HR83

Conserved Domains (1) summary

cd01314
Location:7 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
XM_039079859.2 → XP_038935787.1 dihydropyrimidinase isoform X1

UniProtKB/Swiss-Prot

Q63150, Q642F0

UniProtKB/TrEMBL

A0A8I6AEZ1, A6HR83

Conserved Domains (1) summary

cd01314
Location:7 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...