Mark2 microtubule affinity regulating kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mark2provided by RGD
Official Full Name: microtubule affinity regulating kinase 2provided by RGD
Primary source: RGD:708483
See related: Ensembl:ENSRNOG00000021184 AllianceGenome:RGD:708483
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein N-terminus binding activity; protein kinase activity; and tau protein binding activity. Involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; generation of neurons; and protein phosphorylation. Located in membrane. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 73.1), Spleen (RPKM 64.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213890213..213955417, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204461029..204526247, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222525547..222590727, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
Title: MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
a critical role for MARK2 in overcoming Nogo-66-induced inhibition of axon outgrowth in neurons
Title: MARK2 Rescues Nogo-66-Induced Inhibition of Neurite Outgrowth via Regulating Microtubule-Associated Proteins in Neurons In Vitro.
The results identify MARK2 as an upstream regulator of PINK1 and DeltaN-PINK1 and provide insights into the regulation of mitochondrial trafficking in neurons and neurodegeneration in PD.
Title: Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport.
These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation.
Title: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation.
GSK3beta can also phosphorylate Tau at sites outside the repeat domain, the activation of GSK3beta, and concomitant inactivation of MARK2
Title: Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.
These results indicate that Par1b/MARK2 negatively regulates dendrite development through phosphorylation of MAP2.
Title: Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons.
Tau-induced synaptic decay can be relieved by the activation of MARK2, which can remove tau from the microtubule tracks and reverse the transport block.
Title: Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE120328 (e-PCR)
- UniSTS:247307

MARC_12033-12034:1004018501:1 (e-PCR)
- UniSTS:267314

MARC_15725-15726:1017931544:1 (e-PCR)
- UniSTS:267883

UniSTS:502425 (e-PCR)
- UniSTS:502425

Xtxp339 (e-PCR), detects polymorphism
- UniSTS:502425

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tau-protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables tau-protein kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tau-protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of cell polarity regulating cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in basal cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule bundle	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in microtubule bundle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase MARK2

Names: ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; serine/threonine kinase

NP_001385562.1

EC 2.7.11.1

EC 2.7.11.26

NP_067731.1

EC 2.7.11.1

EC 2.7.11.26

XP_006230941.1

EC 2.7.11.1

EC 2.7.11.26

XP_006230942.1

EC 2.7.11.1

EC 2.7.11.26

XP_006230943.1

EC 2.7.11.1

EC 2.7.11.26

XP_006230945.1

EC 2.7.11.1

EC 2.7.11.26

XP_006230946.1

EC 2.7.11.1

EC 2.7.11.26

XP_006230949.1

EC 2.7.11.1

EC 2.7.11.26

XP_017445128.1

EC 2.7.11.1

EC 2.7.11.26

XP_017445129.1

EC 2.7.11.1

EC 2.7.11.26

XP_038944875.1

EC 2.7.11.1

EC 2.7.11.26

XP_038944878.1

EC 2.7.11.1

EC 2.7.11.26

XP_063128471.1

EC 2.7.11.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398633.1 → NP_001385562.1 serine/threonine-protein kinase MARK2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000081955.1, ENSRNOT00000110931.1

Conserved Domains (3) summary

cd12201
Location:677 → 775

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
NM_021699.3 → NP_067731.1 serine/threonine-protein kinase MARK2 isoform 1

See identical proteins and their annotated locations for NP_067731.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O08679

UniProtKB/TrEMBL

A0A8I5Y5N7

Related

ENSRNOP00000091631.1, ENSRNOT00000111902.1

Conserved Domains (3) summary

cd12201
Location:623 → 721

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213890213..213955417 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230881.5 → XP_006230943.1 serine/threonine-protein kinase MARK2 isoform X3

See identical proteins and their annotated locations for XP_006230943.1

UniProtKB/TrEMBL

A0A8I5ZU08

Conserved Domains (3) summary

cd12201
Location:709 → 807

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_017589640.3 → XP_017445129.1 serine/threonine-protein kinase MARK2 isoform X9

UniProtKB/TrEMBL

A0A8I5Y5N7, A0A8I6GJH6

Related

ENSRNOP00000092104.1

Conserved Domains (3) summary

cd12201
Location:608 → 706

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_063272401.1 → XP_063128471.1 serine/threonine-protein kinase MARK2 isoform X6
XM_006230887.5 → XP_006230949.1 serine/threonine-protein kinase MARK2 isoform X8

UniProtKB/TrEMBL

A0A8I5Y5N7

Conserved Domains (3) summary

cd12201
Location:632 → 730

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006230883.5 → XP_006230945.1 serine/threonine-protein kinase MARK2 isoform X4

UniProtKB/TrEMBL

A0A8I5Y5N7

Conserved Domains (4) summary

cd12201
Location:688 → 786

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

smart00220
Location:53 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_017589639.3 → XP_017445128.1 serine/threonine-protein kinase MARK2 isoform X7

UniProtKB/TrEMBL

A0A8I5ZU08

Conserved Domains (3) summary

cd12201
Location:662 → 760

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_039088947.2 → XP_038944875.1 serine/threonine-protein kinase MARK2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZU08

Conserved Domains (3) summary

cd12201
Location:733 → 831

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006230884.5 → XP_006230946.1 serine/threonine-protein kinase MARK2 isoform X5

UniProtKB/TrEMBL

A0A0G2K6X6, A0A8I5ZU08

Related

ENSRNOP00000073980.2

Conserved Domains (3) summary

cd12201
Location:686 → 784

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006230879.4 → XP_006230941.1 serine/threonine-protein kinase MARK2 isoform X1

UniProtKB/TrEMBL

A0A8I5Y7M0, A0A8I5ZU08

Related

ENSRNOP00000077495.1

Conserved Domains (4) summary

cd12201
Location:742 → 840

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

smart00220
Location:53 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14406
Location:322 → 363

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:52 → 304

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_039088950.2 → XP_038944878.1 serine/threonine-protein kinase MARK2 isoform X3

UniProtKB/TrEMBL

A0A8I5ZU08

Conserved Domains (3) summary

cd12201
Location:709 → 807

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006230880.5 → XP_006230942.1 serine/threonine-protein kinase MARK2 isoform X3

See identical proteins and their annotated locations for XP_006230942.1

UniProtKB/TrEMBL

A0A8I5ZU08

Conserved Domains (3) summary

cd12201
Location:709 → 807

MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2

cd14406
Location:289 → 330

UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins

cd14072
Location:19 → 271

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases