Nr4a3 nuclear receptor subfamily 4, group A, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nr4a3provided by RGD
Official Full Name: nuclear receptor subfamily 4, group A, member 3provided by RGD
Primary source: RGD:61882
See related: Ensembl:ENSRNOG00000005964 AllianceGenome:RGD:61882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NOR-2
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein homodimerization activity. Involved in several processes, including animal organ regeneration; positive regulation of cardiac muscle hypertrophy; and regulation of type B pancreatic cell proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 64.9), Brain (RPKM 12.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (67157141..67198287)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (62361588..62401489)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (63781801..63822890)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats.
Title: Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats.
Loss of Nr4a1 and Nr4a3 impedes production of ATP and ultimately inhibits glucose-stimulated insulin secretion. These data demonstrate for the first time that the orphan nuclear receptors Nr4a1 and Nr4a3 are critical for beta-cell mitochondrial function and insulin secretion.
Title: β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion.
mechanisms of NOR1 regulation
Title: Epigenetic regulation of the NR4A orphan nuclear receptor NOR1 by histone acetylation.
The expression of Nur77, Nurr1 and Nor 1 in the white adipose tissue is regulated by nutritional and hormonal status.
Title: Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency.
Nkx6.1 and Nr4a receptors induce components of the anaphase-promoting complex, including ubiquitin-conjugating enzyme E2C, resulting in degradation of the cell cycle inhibitor p21
Title: Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury
Title: Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury.
differential expression of Nor1 may contribute to the differences in metabolic regulation between high running capacity (HCR) and low running capacity (LCR) phenotypes
Title: Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1?
Baseline level of Nor-1 is higher in the Wistar-Kyoto rat model compared to comparison control Sprague-Dawley rats.
Title: Nuclear orphan receptor Nor-1 contributes to depressive behavior in the Wistar-Kyoto rat model of depression.
platelet-derived growth factor-induced NOR1 transcription in smooth muscle cell is mediated through cAMP-response element-binding protein-dependent transactivation of the NOR1 promoter [NOR1]
Title: The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.
RT-PCR revealed up-regulation of several NR4A transcriptional targets (Ucp-3, Ampk-gamma3, Pgc-1alpha and Pgc-1beta) in skeletal muscle of diet-restricted animals
Title: Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

PMC133552P1 (e-PCR)
- UniSTS:270631

PMC133552P2 (e-PCR)
- UniSTS:270632

D5Wox30 (e-PCR)
- UniSTS:239934

RH141611 (e-PCR)
- UniSTS:223605

Nr4a3 (e-PCR), detects polymorphism
- UniSTS:256689

BF390776 (e-PCR)
- UniSTS:249554

Nr4a3 (e-PCR), detects polymorphism
- UniSTS:536541

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in cellular respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to catecholamine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to catecholamine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to leptin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leptin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in common myeloid progenitor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in gastrulation	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within semicircular canal morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vestibular reflex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor subfamily 4 group A member 3

Names: neuron-derived orphan receptor 1; neuron-derived orphan receptor 1/2; nuclear hormone receptor NOR-1/NOR-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031628.3 → NP_113816.1 nuclear receptor subfamily 4 group A member 3

See identical proteins and their annotated locations for NP_113816.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51179, Q2XPY2, Q63516, Q9QWQ3

UniProtKB/TrEMBL

A6KJG2

Related

ENSRNOP00000008302.2, ENSRNOT00000008302.5

Conserved Domains (2) summary

cd06969
Location:292 → 366

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:398 → 628

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

67157141..67198287

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110691.2 → XP_038966619.1 nuclear receptor subfamily 4 group A member 3 isoform X1

UniProtKB/Swiss-Prot

P51179, Q2XPY2, Q63516, Q9QWQ3

UniProtKB/TrEMBL

A6KJG2

Conserved Domains (2) summary

cd06969
Location:292 → 366

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:398 → 628

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_039110692.2 → XP_038966620.1 nuclear receptor subfamily 4 group A member 3 isoform X1

UniProtKB/Swiss-Prot

P51179, Q2XPY2, Q63516, Q9QWQ3

UniProtKB/TrEMBL

A6KJG2

Conserved Domains (2) summary

cd06969
Location:292 → 366

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:398 → 628

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_063288331.1 → XP_063144401.1 nuclear receptor subfamily 4 group A member 3 isoform X1

UniProtKB/Swiss-Prot

P51179, Q2XPY2, Q63516, Q9QWQ3

UniProtKB/TrEMBL

A6KJG2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017352.1: Suppressed sequence

Description

NM_017352.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.