Gjb4 gap junction protein, beta 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gjb4provided by RGD
Official Full Name: gap junction protein, beta 4provided by RGD
Primary source: RGD:621829
See related: Ensembl:ENSRNOG00000026910 AllianceGenome:RGD:621829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cxnb; Gjb4o; Cx30.3; Cnx30.3; Cx30.3o; Cnx30.3o
Summary: Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling and gap junction-mediated intercellular transport. Predicted to act upstream of or within olfactory behavior and sensory perception of smell. Predicted to be located in cell junction; nucleolus; and nucleoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of connexin complex. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and erythrokeratodermia variabilis et progressiva 2. Orthologous to human GJB4 (gap junction protein beta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 6.8), Lung (RPKM 1.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (144948231..144964014, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (139675776..139679551, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (145416343..145421122, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate the presence and localization of Cx30.3 in the rat cochlea.
Title: Novel expression patterns of connexin 30.3 in adult rat cochlea.

Submit: New GeneRIF Correction

General gene information

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Markers

Gjb4 (e-PCR), detects polymorphism
- UniSTS:226050

RH142445 (e-PCR)
- UniSTS:231692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IEA Inferred from Electronic Annotation more info
enables gap junction channel activity	ISO Inferred from Sequence Orthology more info
enables gap junction channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in gap junction-mediated intercellular transport	IEA Inferred from Electronic Annotation more info
involved_in gap junction-mediated intercellular transport	ISO Inferred from Sequence Orthology more info
involved_in gap junction-mediated intercellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in olfactory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within olfactory behavior	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
part_of connexin complex	ISO Inferred from Sequence Orthology more info
part_of connexin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: gap junction beta-4 protein

Names: connexin 30.3o; connexin b; connexin-30.3; gap junction membrane channel protein beta 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389258.1 → NP_001376187.1 gap junction beta-4 protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P36380

UniProtKB/TrEMBL

A6ISD2, F1M8I1

Related

ENSRNOP00000033893.2, ENSRNOT00000037128.4

Conserved Domains (1) summary

pfam00029
Location:2 → 210

Connexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

144948231..144964014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287084.1 → XP_063143154.1 gap junction beta-4 protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_053984.2: Suppressed sequence

Description

NM_053984.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.