Fgf16 fibroblast growth factor 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgf16provided by RGD
Official Full Name: fibroblast growth factor 16provided by RGD
Primary source: RGD:71052
See related: Ensembl:ENSRNOG00000061530 AllianceGenome:RGD:71052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables fibroblast growth factor receptor binding activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of brown fat cell proliferation. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in syndactyly type 8. Orthologous to human FGF16 (fibroblast growth factor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 151.6) and Adrenal (RPKM 8.7) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (74882863..74893598)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (70816658..70828028)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (76786728..76796311)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiac Fgf-16 expression supports cardiomyocyte survival and increases resistance to doxorubicin cytotoxicity.
Title: Cardiac Fgf-16 Expression Supports Cardiomyocyte Survival and Increases Resistance to Doxorubicin Cytotoxicity.
Expression and release of FGF-16 in the neonatal myocardium interfere with cardiac myocyte proliferative potential by altering the local signaling environment via modulation of PKC activation and cell cycle-related gene expression.
Title: FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development.
FGF-16 employs a unique bipartite signal sequence that is not cleaved, although it shares the same secretory machinery used by secreted proteins with cleavable signal sequences.
Title: Secretion of FGF-16 requires an uncleaved bipartite signal sequence.

Submit: New GeneRIF Correction

General gene information

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Markers

Fgf16 (e-PCR), detects polymorphism
- UniSTS:507918

Fgf16 (e-PCR), detects polymorphism
- UniSTS:516667

Fgf16 (e-PCR), detects polymorphism
- UniSTS:532400

NoName (e-PCR)
- UniSTS:485301

Fgf16 (e-PCR), detects polymorphism
- UniSTS:258262

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of brown fat cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 16

Names: FGF-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021867.4 → NP_068639.1 fibroblast growth factor 16

See identical proteins and their annotated locations for NP_068639.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

O54769

UniProtKB/TrEMBL

A0A8I6AHM0, A6IV34

Related

ENSRNOP00000071308.1, ENSRNOT00000090665.2

Conserved Domains (1) summary

pfam00167
Location:61 → 187

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

74882863..74893598

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100003.2 → XP_038955931.1 fibroblast growth factor 16 isoform X1

Conserved Domains (1) summary

cl00060
Location:61 → 126

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...