Rab40c Rab40c, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab40cprovided by RGD
Official Full Name: Rab40c, member RAS oncogene familyprovided by RGD
Primary source: RGD:727914
See related: Ensembl:ENSRNOG00000020067 AllianceGenome:RGD:727914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GDP binding activity and GTP binding activity. Predicted to be involved in protein localization to plasma membrane. Located in perinuclear region of cytoplasm. Orthologous to human RAB40C (RAB40C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 57.2), Brain (RPKM 53.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15405436..15440659, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14900926..14936153, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15247913..15283111, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel Rab protein, Rab40c, was cloned from an oligodendrocyte cDNA library. Rab40c is localized in the perinuclear recycling compartment, suggesting its involvement in endocytic events such as receptor recycling.
Title: Vesicle transport in oligodendrocytes: probable role of Rab40c protein.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141016 (e-PCR)
- UniSTS:223016

D17Jcs49 (e-PCR), detects polymorphism
- UniSTS:259290

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in myelination	NAS Non-traceable Author Statement more info	PubMed
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in receptor recycling	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-40C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182675.2 → NP_872616.1 ras-related protein Rab-40C

See identical proteins and their annotated locations for NP_872616.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A2VCW4, Q6Y2E6

Related

ENSRNOP00000027266.3, ENSRNOT00000027266.4

Conserved Domains (2) summary

cd04121
Location:9 → 281

Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c

cd03742
Location:187 → 229

SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...