Etfbkmt electron transfer flavoprotein subunit beta lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Etfbkmtprovided by RGD
Official Full Name: electron transfer flavoprotein subunit beta lysine methyltransferaseprovided by RGD
Primary source: RGD:735147
See related: Ensembl:ENSRNOG00000036918 AllianceGenome:RGD:735147
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mettl20; ETFB-KMT
Summary: Predicted to enable heat shock protein binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of electron transfer activity; negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase; and peptidyl-lysine trimethylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial matrix. Orthologous to human ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 121.0), Spleen (RPKM 105.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (183871819..183936843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (182140492..182204635)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (183655968..183665757)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138652 (e-PCR)
- UniSTS:220739

RH142908 (e-PCR)
- UniSTS:232155

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine trimethylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: electron transfer flavoprotein beta subunit lysine methyltransferase

Names: ETFB lysine methyltransferase; methyltransferase like 20; methyltransferase-like protein 20; protein N-lysine methyltransferase METTL20

NP_942067.1

EC 2.1.1.-

XP_006237763.1

EC 2.1.1.-

XP_038963650.1

EC 2.1.1.-

XP_038963652.1

EC 2.1.1.-

XP_038963653.1

EC 2.1.1.-

XP_063142266.1

EC 2.1.1.-

XP_063142267.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198772.2 → NP_942067.1 electron transfer flavoprotein beta subunit lysine methyltransferase

See identical proteins and their annotated locations for NP_942067.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q6P7Q0

Related

ENSRNOP00000052309.2, ENSRNOT00000055442.3

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

183871819..183936843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107724.2 → XP_038963652.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:58 → 158

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039107725.2 → XP_038963653.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

Conserved Domains (1) summary

cl17173
Location:58 → 168

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039107722.2 → XP_038963650.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

UniProtKB/Swiss-Prot

Q6P7Q0

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063286197.1 → XP_063142267.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X4
XM_063286196.1 → XP_063142266.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2
XM_006237701.5 → XP_006237763.1 electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

See identical proteins and their annotated locations for XP_006237763.1

UniProtKB/Swiss-Prot

Q6P7Q0

Conserved Domains (1) summary

cl17173
Location:58 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...