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    ECM38 gamma-glutamyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851006, updated on 17-May-2024

    Summary

    Gene symbol
    ECM38
    Gene description
    gamma-glutamyltransferase
    Primary source
    FungiDB:YLR299W
    Locus tag
    YLR299W
    See related
    SGD:S000004290; AllianceGenome:SGD:S000004290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIS2
    Summary
    Enables glutathione hydrolase activity. Involved in glutathione catabolic process and xenobiotic metabolic process. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See ECM38 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (726069..728051)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yhc1p Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene Hri1p

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gamma-glutamyltransferase
    NP_013402.1
    • Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      726069..728051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182187.1NP_013402.1  TPA: gamma-glutamyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYU3, Q05902
      UniProtKB/TrEMBL
      A0A8H4BZN0, A7A1I0, B3RHH8, C7GVU0, G2WJC1, N1P1J5
      Conserved Domains (1) summary
      cl19223
      Location:101652
      G_glu_transpept; Gamma-glutamyltranspeptidase