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    GSP1 Ran GTPase GSP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851000, updated on 17-May-2024

    Summary

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    Gene symbol
    GSP1
    Gene description
    Ran GTPase GSP1
    Primary source
    FungiDB:YLR293C
    Locus tag
    YLR293C
    See related
    SGD:S000004284; AllianceGenome:SGD:S000004284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CNR1; CST17
    Summary
    Enables GTPase activity. Involved in several processes, including exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleocytoplasmic transport; and regulation of nucleocytoplasmic transport. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GSP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (720771..721430, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2B subunit beta Neighboring gene Sec63 complex subunit SEC72 Neighboring gene F1F0 ATP synthase subunit h Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p. Oki M, et al. Mol Gen Genet, 1998 Apr. PMID 9604885
    2. A 2.1-Å-resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition. Saito N, et al. J Mol Biol, 2013 Jan 23. PMID 23164569
    3. Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway. Hayashi N, et al. Biochem Biophys Res Commun, 2007 Feb 9. PMID 17187759
    4. Functional analysis of the yeast Ran exchange factor Prp20p: in vivo evidence for the RanGTP gradient model. Akhtar N, et al. Mol Genet Genomics, 2001 Jul. PMID 11523802
    5. Crystallization and preliminary X-ray diffraction analysis of the Saccharomyces cerevisiae ran-binding protein Mog1p. Baker RP, et al. Acta Crystallogr D Biol Crystallogr, 2000 Feb. PMID 10666614

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systems-level effects of allosteric perturbations to a model molecular switch.
      Title: Systems-level effects of allosteric perturbations to a model molecular switch.
    2. Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.
      Title: Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.
    3. Cex1p recruits Rna1p from the cytoplasm to the nuclear pore complex and facilitates Rna1p activation of the GTPase activity of Gsp1p by enabling Rna1p to gain access to Gsp1p-GTP bound to the Los1p-tRNA-Gsp1p-GTP export complex.
      Title: Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.
    4. Study proved that the additional beta-wedge in Prp20p is essential for the interaction between Prp20p and Gsp1p.
      Title: The 1.9Å crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones.
    5. Thus, the Gtr1p-Gtr2p cycle was suggested to regulate the Ran cycle through Yrb2p.
      Title: Saccharomyces cerevisiae GTPase complex: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p.
    6. Results suggest that the GSP1 pathway could regulate proper telomeric function in yeast through Sir4p.
      Title: The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ran GTPase GSP1
    NP_013396.1
    • Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      720771..721430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182181.1 → NP_013396.1  TPA: Ran GTPase GSP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYT9, P32835
      UniProtKB/TrEMBL
      A0A6A5PUD0, A7A1H6, B3RHH3, B5VNJ9, C7GVU4, C8ZDQ7, G2WJB7, N1NZK2
      Conserved Domains (1) summary
      PTZ00132
      Location:4 → 216
      PTZ00132; GTP-binding nuclear protein Ran; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32835.1

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