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    SSO1 syntaxin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855844, updated on 9-Jun-2024

    Summary

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    Gene symbol
    SSO1
    Gene description
    syntaxin
    Primary source
    FungiDB:YPL232W
    Locus tag
    YPL232W
    See related
    SGD:S000006153; AllianceGenome:SGD:S000006153; VEuPathDB:YPL232W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity and anion binding activity. Involved in ascospore-type prospore assembly and vesicle fusion. Located in fungal-type vacuole membrane; plasma membrane; and prospore membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Hirschsprung's disease; congenital diarrhea; familial hemophagocytic lymphohistiocytosis 4; and generalized epilepsy with febrile seizures plus 9. Orthologous to several human genes including STX4 (syntaxin 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SSO1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (107275..108147)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V0 sector ATPase subunit c' Neighboring gene MIND complex subunit NSL1 Neighboring gene trifunctional fatty acid synthase subunit FAS2 Neighboring gene Usv1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The shape of the transmembrane domain is a novel endocytosis signal for single-spanning membrane proteins. González Montoro A, et al. J Cell Sci, 2017 Nov 15. PMID 28972131
    2. Transmembrane organization of yeast syntaxin-analogue Sso1p. Zhang Y, et al. Biochemistry, 2006 Apr 4. PMID 16566591
    3. Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly. Munson M, et al. Nat Struct Biol, 2000 Oct. PMID 11017200
    4. Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion. Lai Y, et al. Phys Biol, 2015 Apr 21. PMID 25898400, Free PMC Article
    5. Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex. Quiroga R, et al. J Cell Sci, 2013 Dec 1. PMID 24105265

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The shape of the exoplasmic hemi-transmembrane domain, in addition to the length of the entire transmembrane domain, determine retention in the Golgi or exit to the plasma membrane of SFT1 and SSO1 proteins.
      Title: Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex.
    2. The Sso1, but not SSo2, is essential for prospore membrane formation.
      Title: Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation.
    3. Data show that the required function of the NH2-terminal regulatory domain (NRD) of the yeast plasma membrane syntaxin, Sso1p, can be circumvented when t-SNARE complex formation is made intramolecular.
      Title: An intramolecular t-SNARE complex functions in vivo without the syntaxin NH2-terminal regulatory domain.
    4. EPR analysis of spin-labeled mutants showed that the transmembrane domain of Sso1p is a well-defined membrane spanning alpha-helix.
      Title: Transmembrane organization of yeast syntaxin-analogue Sso1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNAP receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore-type prospore assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascospore-type prospore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syntaxin
    NP_015092.1
    • Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      107275..108147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184046.1 → NP_015092.1  TPA: syntaxin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3D8, P32867
      UniProtKB/TrEMBL
      A0A6A5Q6Q1, A6ZW23, B3LKJ9, B5VSV0, C7GU71, C8ZIE7, G2WNV3, N1P2I2
      Conserved Domains (1) summary
      COG5074
      Location:1 → 268
      COG5074; t-SNARE complex subunit, syntaxin [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32867.2

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