Dnah6 dynein, axonemal, heavy chain 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnah6provided by RGD
Official Full Name: dynein, axonemal, heavy chain 6provided by RGD
Primary source: RGD:621797
See related: Ensembl:ENSRNOG00000015581 AllianceGenome:RGD:621797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: axo a; Dnahc6
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule. Predicted to be part of dynein complex. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 64.4), Testes (RPKM 64.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 77

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106622235..106842461, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (105064123..105284361, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100936834..101157511, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D4Rat175 (e-PCR), detects polymorphism
- UniSTS:227735

D4UIA3 (e-PCR)
- UniSTS:239536

AU027878 (e-PCR)
- UniSTS:112876

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein axonemal heavy chain 6

Names: axonemal dynein heavy chain; dynein heavy chain 6, axonemal; dynein, axonemal, heavy polypeptide 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419792.1 → NP_001406721.1 dynein axonemal heavy chain 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

F1LXT8

Related

ENSRNOP00000020894.7, ENSRNOT00000020894.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

106622235..106842461 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108712.2 → XP_038964640.1 dynein axonemal heavy chain 6 isoform X1

UniProtKB/TrEMBL

A0A8I6ADI4

Conserved Domains (4) summary

COG5245
Location:1127 → 3774

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:887 → 1307

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1441 → 1767

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:3827 → 4152

Dynein_C; Dynein heavy chain C-terminal domain