U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Usp30 Ubiquitin specific protease 30 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31519, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Usp30provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 30provided by FlyBase
    Primary source
    FLYBASE:FBgn0029819
    Locus tag
    Dmel_CG3016
    See related
    AllianceGenome:FB:FBgn0029819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3016; Dmel\CG3016; dUSP30; Q9W462; USP30
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in response to paraquat. Predicted to be active in cytosol and nucleus. Is expressed in adult head. Orthologous to human USP30 (ubiquitin specific peptidase 30). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Usp30 in Genome Data Viewer
    Location:
    5C5-5C6; 1-14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5877000..5879787, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5771033..5773820, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glycosylphosphatidylinositol anchor attachment 1 Neighboring gene males absent on the first Neighboring gene long non-coding RNA:CR45668 Neighboring gene uncharacterized protein Neighboring gene Actin 5C

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitochondrial dynamics and mitophagy in Parkinson's disease: A fly point of view. Von Stockum S, et al. Neurobiol Dis, 2016 Jun. PMID 26550693
    2. Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila. Cornelissen T, et al. Elife, 2018 May 29. PMID 29809156, Free PMC Article
    3. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Bingol B, et al. Nature, 2014 Jun 19. PMID 24896179
    4. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Kind J, et al. Genes Dev, 2007 Aug 15. PMID 17699750, Free PMC Article
    5. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K6-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to paraquat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin specific protease 30
    Names
    CG3016-PA
    CG3016-PB
    Usp30-PA
    Usp30-PB
    ubiquitin specific peptidase 30
    NP_001284912.1
    NP_572274.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5877000..5879787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132046.3 → NP_572274.1  ubiquitin specific protease 30, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W462
      Related
      FBpp0070793
      Conserved Domains (3) summary
      cd02662
      Location:323 → 548
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:39 → 139
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:304 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001297983.1 → NP_001284912.1  ubiquitin specific protease 30, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W462
      Conserved Domains (3) summary
      cd02662
      Location:323 → 548
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:39 → 139
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:304 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W462.1 Q9W462

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous