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    kraken [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33265, updated on 10-May-2024

    Summary

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    Official Symbol
    krakenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020545
    Locus tag
    Dmel_CG3943
    See related
    AllianceGenome:FB:FBgn0020545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3943; Dmel\CG3943; Kra; Kraken; SERHL; SERHL2
    Summary
    Enables serine hydrolase activity. Involved in digestion and response to toxic substance. Is expressed in several structures, including embryonic head segment; embryonic main segment of Malpighian tubule; gut section; imaginal disc; and presumptive embryonic/larval system. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See kraken in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (852768..854539)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (852768..854539)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene drongo Neighboring gene long non-coding RNA:CR44060 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45345 Neighboring gene uncharacterized protein Neighboring gene mir-375 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. Fernández-Fúnez P, et al. EMBO J, 1998 Dec 1. PMID 9843490, Free PMC Article
    2. Identification and characterization of kraken, a gene encoding a putative hydrolytic enzyme in Drosophila melanogaster. Edwin Chan HY, et al. Gene, 1998 Nov 19. PMID 9831651
    3. Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genes. Keegan KP, et al. PLoS Comput Biol, 2007 Nov. PMID 17983263, Free PMC Article
    4. Molecular effects of dADD1 misexpression in chromatin organization and transcription. Meyer-Nava S, et al. BMC Mol Cell Biol, 2020 Mar 23. PMID 32293240, Free PMC Article
    5. Multiple-stress analysis for isolation of Drosophila longevity genes. Wang HD, et al. Proc Natl Acad Sci U S A, 2004 Aug 24. PMID 15308776, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in digestion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kraken
    Names
    CG3943-PA
    CG3943-PB
    kraken-PA
    kraken-PB
    NP_001259847.1
    NP_477265.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      852768..854539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057917.4 → NP_477265.1  kraken, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18391
      UniProtKB/TrEMBL
      M9PBM0
      Related
      FBpp0077681
      Conserved Domains (2) summary
      COG0596
      Location:61 → 329
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:63 → 159
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_001272918.1 → NP_001259847.1  kraken, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18391
      UniProtKB/TrEMBL
      M9PBM0
      Conserved Domains (2) summary
      COG0596
      Location:61 → 329
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:63 → 159
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBM0 M9PBM0
    O18391.1 O18391

    Gene LinkOut

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