inaC inactivation no afterpotential C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: inaCprovided by FlyBase
Official Full Name: inactivation no afterpotential Cprovided by FlyBase
Primary source: FLYBASE:FBgn0004784
Locus tag: Dmel_CG6518
See related: AllianceGenome:FB:FBgn0004784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6518; Dmel\CG6518; Dpkc2; dPKC53E; dPKC53E(ey); ePKC; eye PKC; eye-PKC; eyePKC; inac; InaC; INAC; PK-C; PKC; PKC 53E; pkc-2; Pkc2; PKC2; PKCi; PKCinac
Summary: Predicted to enable protein kinase C activity. Involved in several processes, including detection of light stimulus; phospholipase C-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of clathrin-dependent endocytosis. Located in rhabdomere. Colocalizes with endosome. Is expressed in several structures, including head; spermatozoon; and visual system. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma (multiple); ovarian cancer; and spinocerebellar ataxia type 14. Orthologous to human PRKCA (protein kinase C alpha); PRKCB (protein kinase C beta); and PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 53E1-53E1; 2-81 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16898535..16901575)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12786040..12789080)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of light stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with endosome	IDA Inferred from Direct Assay more info	PubMed
part_of inaD signaling complex	TAS Traceable Author Statement more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inactivation no afterpotential C

Names: CG6518-PA; PKC-eye; Protein-kinase-2; eye-PKC; eye-protein-kinase C; eye-specific PKC; inaC-PA; protein kinase C; protein kinase-c2; protein-kinase-C

NP_476863.1

EC 2.7.11.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16898535..16901575

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057515.3 → NP_476863.1 inactivation no afterpotential C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476863.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13677, Q9V7V5

Related

FBpp0086196

Conserved Domains (4) summary

cd04026
Location:194 → 324

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:371 → 629

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05570
Location:375 → 692

STKc_PKC; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C

pfam00130
Location:72 → 124

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)