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    Hsp23 Heat shock protein 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39077, updated on 10-May-2024

    Summary

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    Official Symbol
    Hsp23provided by FlyBase
    Official Full Name
    Heat shock protein 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0001224
    Locus tag
    Dmel_CG4463
    See related
    AllianceGenome:FB:FBgn0001224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    23; CG4463; Dmel20.6; Dmel\CG4463; DmHsp23; DmHSP23; hsp 22K; hsp 23; hsp 23K; hsp-23; Hsp-23; hsp23; HSP23; hsp23/22; HSP23/IAP; small hsp locus 67B
    Summary
    Enables unfolded protein binding activity. Involved in several processes, including chaperone-mediated protein folding; cold acclimation; and protein refolding. Located in cytosol. Is expressed in several structures, including adult heart; chordotonal organ precursor cell; extended germ band embryo; ventral midline of embryo; and ventral nerve cord. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B); HSPB2 (heat shock protein family B (small) member 2); and HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Hsp23 in Genome Data Viewer
    Location:
    67B3-67B3; 3-29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9381882..9382765)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9374982..9375865)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 26 Neighboring gene antisense RNA:CR43481 Neighboring gene Heat shock gene 67Ba Neighboring gene Heat shock protein 27 Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster. Gu X, et al. Insect Biochem Mol Biol, 2021 Dec. PMID 34562590
    2. Maternal loading of a small heat shock protein increases embryo thermal tolerance in Drosophila melanogaster. Lockwood BL, et al. J Exp Biol, 2017 Dec 1. PMID 29097593, Free PMC Article
    3. Drosophila melanogaster is polymorphic for a specific repeated (CATA) sequence in the regulatory region of hsp23. Frydenberg J, et al. Gene, 1999 Aug 20. PMID 10452944
    4. Heat shock and ecdysterone activation of the Drosophila melanogaster hsp23 gene; a sequence element implied in developmental regulation. Mestril R, et al. EMBO J, 1986 Jul. PMID 3091364, Free PMC Article
    5. Identification of a sequence element in the promoter of the Drosophila melanogaster hsp23 gene that is required for its heat activation. Mestril R, et al. EMBO J, 1985 Nov. PMID 2998770, Free PMC Article

    See all (269) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster.
      Title: Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster.
    2. Small heat shock proteins determine synapse number and neuronal activity during development.
      Title: Small heat shock proteins determine synapse number and neuronal activity during development.
    3. Hsp22 and Hsp23 play important roles in the recovery from chill coma in adult males, and suggest that these contribute to adaptive responses to fluctuating thermal conditions.
      Title: Knocking down expression of Hsp22 and Hsp23 by RNA interference affects recovery from chill coma in Drosophila melanogaster.
    4. The data demonstrate a specific over-expression phenotype for hsp22 and suggest that hsp22 interacts with heat and oxidative stress resistance pathways.
      Title: Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster.
    5. We conclude that histone acetylation stimulates the transcription initiation and promotes the transcription elongation, thereby up-regulating both basal and inducible expression of hsp22 in D. melanogaster.
      Title: Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in cold acclimation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 23
    Names
    CG4463-PA
    CG4463-PB
    Hsp 23
    Hsp23-PA
    Hsp23-PB
    heat-shock protein 23
    protein 23

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9381882..9382765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259765.2 → NP_001246694.1  heat shock protein 23, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02516, Q9VSX5
      UniProtKB/TrEMBL
      M9NE68
      Conserved Domains (2) summary
      cd06526
      Location:67 → 145
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
      COG0071
      Location:69 → 161
      IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]

    2. NM_079275.4 → NP_523999.1  heat shock protein 23, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02516, Q9VSX5
      UniProtKB/TrEMBL
      M9NE68
      Related
      FBpp0076181
      Conserved Domains (2) summary
      cd06526
      Location:67 → 145
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
      COG0071
      Location:69 → 161
      IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NE68 M9NE68
    P02516.2 P02516

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