U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PGAP3 Post-GPI attachment to proteins 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35570, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PGAP3provided by FlyBase
    Official Full Name
    Post-GPI attachment to proteins 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033088
    Locus tag
    Dmel_CG3271
    See related
    AllianceGenome:FB:FBgn0033088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3271; Dmel\CG3271
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be intrinsic component of endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PGAP3 in Genome Data Viewer
    Location:
    42C4-42C4; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6673604..6675061)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2561109..2562566)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate C5-epimerase Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene Tyrosine decarboxylase 1 Neighboring gene long non-coding RNA:CR44164

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid. Dejima K, et al. J Biol Chem, 2013 Nov 29. PMID 24133213, Free PMC Article
    2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on ester bonds ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Post-GPI attachment to proteins 3
    Names
    CG3271-PA
    CG3271-PB
    PGAP3-PA
    PGAP3-PB
    Post-GPI attachment to proteins 3 ortholog
    NP_610223.1
    NP_724485.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6673604..6675061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165482.4 → NP_724485.1  Post-GPI attachment to proteins 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6N0, Q7K0P4
      Related
      FBpp0085452
      Conserved Domains (1) summary
      pfam04080
      Location:65 → 306
      Per1; Per1-like

    2. NM_136379.4 → NP_610223.1  Post-GPI attachment to proteins 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610223.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K0P4
      Related
      FBpp0085453
      Conserved Domains (1) summary
      pfam04080
      Location:65 → 313
      Per1; Per1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0P4.2 Q7K0P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools