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    ninaG [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41369, updated on 10-May-2024

    Summary

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    Official Symbol
    ninaGprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037896
    Locus tag
    Dmel_CG6728
    See related
    AllianceGenome:FB:FBgn0037896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6728; Dmel\CG6728; NinaG
    Summary
    Enables oxidoreductase activity. Involved in several processes, including protein localization to rhabdomere; rhabdomere morphogenesis; and rhodopsin metabolic process. Is expressed in adult head; lch5 scolopidial ligament cell; and scolopidial ligament cell. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ninaG in Genome Data Viewer
    Location:
    86E5-86E5; 3-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11419376..11421693, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7245098..7247415, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene brother of rumpel Neighboring gene uncharacterized protein Neighboring gene Spastizin Neighboring gene Ribosomal protein L24-like Neighboring gene D-aminoacyl-tRNA deacylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Drosophila ninaG oxidoreductase in visual pigment chromophore biogenesis. Ahmad ST, et al. J Biol Chem, 2006 Apr 7. PMID 16464863
    2. Heterologous expression of bovine rhodopsin in Drosophila photoreceptor cells. Ahmad ST, et al. Invest Ophthalmol Vis Sci, 2006 Sep. PMID 16936079
    3. The Drosophila ninaG oxidoreductase acts in visual pigment chromophore production. Sarfare S, et al. J Biol Chem, 2005 Mar 25. PMID 15640158
    4. Chromophore-Independent Roles of Opsin Apoproteins in Drosophila Mechanoreceptors. Katana R, et al. Curr Biol, 2019 Sep 9. PMID 31447373
    5. Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Takeuchi H, et al. Biochem J, 2005 Aug 1. PMID 15813704, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization to rhabdomere IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ninaG
    Names
    CG6728-PA
    CG6728-PB
    ninaG-PA
    ninaG-PB
    NP_001247047.1
    NP_650070.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11419376..11421693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260118.1 → NP_001247047.1  ninaG, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSH3, Q9VGP2
      UniProtKB/TrEMBL
      A0A0B4K737
      Conserved Domains (3) summary
      COG2303
      Location:72 → 572
      BetA; Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]
      pfam05199
      Location:419 → 566
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:119 → 311
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_141813.2 → NP_650070.1  ninaG, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGP2
      Related
      FBpp0081880, FBtr0082404
      Conserved Domains (3) summary
      COG2303
      Location:72 → 588
      BetA; Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]
      pfam05199
      Location:435 → 582
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:119 → 327
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K737 A0A0B4K737
    Q9VGP2.2 Q9VGP2

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