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    Zfp141 zinc finger protein 141 [ Mus musculus (house mouse) ]

    Gene ID: 434178, updated on 12-May-2024

    Summary

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    Official Symbol
    Zfp141provided by MGI
    Official Full Name
    zinc finger protein 141provided by MGI
    Primary source
    MGI:MGI:3584269
    See related
    Ensembl:ENSMUSG00000092416 AllianceGenome:MGI:3584269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.1), CNS E11.5 (RPKM 2.9) and 25 other tissues See more
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    Genomic context

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    See Zfp141 in Genome Data Viewer
    Location:
    7 B3; 7 28.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (42122810..42155171, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (42473386..42505778, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 60 Neighboring gene RIKEN cDNA 4933421I07 gene Neighboring gene STARR-seq mESC enhancer starr_18739 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4921 Neighboring gene predicted gene, 35353 Neighboring gene STARR-seq mESC enhancer starr_18740 Neighboring gene STARR-seq mESC enhancer starr_18741 Neighboring gene predicted gene, 53386 Neighboring gene STARR-seq mESC enhancer starr_18742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 141

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309388.2 → NP_001296317.1  zinc finger protein 141 isoform 1

      See identical proteins and their annotated locations for NP_001296317.1

      Status: VALIDATED

      Source sequence(s)
      AC102606
      Consensus CDS
      CCDS85276.1
      UniProtKB/TrEMBL
      G3UY09
      Related
      ENSMUSP00000133899.2, ENSMUST00000174407.3
      Conserved Domains (4) summary
      smart00349
      Location:18 → 78
      KRAB; krueppel associated box
      COG5048
      Location:445 → 685
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:424 → 449
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001309389.2 → NP_001296318.1  zinc finger protein 141 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102606
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:399 → 639
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:534 → 554
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:602 → 626
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001421545.1 → NP_001408474.1  zinc finger protein 141 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102606
      UniProtKB/TrEMBL
      G3UY09

    4. NM_001421546.1 → NP_001408475.1  zinc finger protein 141 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102606
      UniProtKB/TrEMBL
      G3UY09

    5. NM_001421548.1 → NP_001408477.1  zinc finger protein 141 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102606

    6. NM_001421550.1 → NP_001408479.1  zinc finger protein 141 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102606

    7. NM_001421553.1 → NP_001408482.1  zinc finger protein 141 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102606

    8. NM_001421555.1 → NP_001408484.1  zinc finger protein 141 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102606

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      42122810..42155171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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