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    Was WASP actin nucleation promoting factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317371, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Wasprovided by RGD
    Official Full Name
    WASP actin nucleation promoting factorprovided by RGD
    Primary source
    RGD:1563567
    See related
    Ensembl:ENSRNOG00000031058 AllianceGenome:RGD:1563567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    WASP
    Summary
    Predicted to enable SH3 domain binding activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; positive regulation of nucleobase-containing compound metabolic process; and regulation of actin filament organization. Predicted to act upstream of or within several processes, including actin filament polymerization; cellular response to interferon-gamma; and endosomal transport. Predicted to be located in several cellular components, including actin filament; phagocytic vesicle; and site of double-strand break. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to human WAS (WASP actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 230.7), Spleen (RPKM 214.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Was in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17077057..17085802)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14405105..14413850)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15155246..15164099)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 3 Neighboring gene WD repeat domain 13 Neighboring gene U6 spliceosomal RNA Neighboring gene SUV39H1 histone lysine methyltransferase Neighboring gene glyoxalase domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. Lang PA, et al. J Allergy Clin Immunol, 2013 Mar. PMID 23141740, Free PMC Article
    2. Wiskott-Aldrich syndrome protein may be critical for CD8(+) T cell function following MCMV infection. Li S, et al. Cell Immunol, 2019 Apr. PMID 30981413
    3. Wiskott-Aldrich syndrome protein is needed for vaccinia virus pathogenesis. Guerra S, et al. J Virol, 2005 Feb. PMID 15681416, Free PMC Article
    4. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Derry JM, et al. Cell, 1994 Aug 26. PMID 8069912
    5. Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1. Lafouresse F, et al. Immunology, 2012 Oct. PMID 22804504, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine phosphorylation of WASP enhanced the ability of WASP to stimulate actin polymerization in mammalian cell lysates
      Title: Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of T cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin nucleation-promoting factor WAS
    Names
    Wiskott-Aldrich syndrome homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398747.1 → NP_001385676.1  actin nucleation-promoting factor WAS

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      B0BN43
      Related
      ENSRNOP00000066881.2, ENSRNOT00000073289.4
      Conserved Domains (3) summary
      pfam00568
      Location:36 → 145
      WH1; WH1 domain
      pfam00786
      Location:237 → 294
      PBD; P21-Rho-binding domain
      cl41728
      Location:435 → 449
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17077057..17085802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108248.1: Suppressed sequence

      Description
      NM_001108248.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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