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    Pcbp4 poly(rC) binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363133, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pcbp4provided by RGD
    Official Full Name
    poly(rC) binding protein 4provided by RGD
    Primary source
    RGD:1307910
    See related
    Ensembl:ENSRNOG00000012406 AllianceGenome:RGD:1307910
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in negative regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and regulation of mRNA stability. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 194.0), Kidney (RPKM 120.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcbp4 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115971751..115981987)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107092688..107103276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115154848..115165706)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14A Neighboring gene uncharacterized LOC134480228 Neighboring gene abhydrolase domain containing 14b Neighboring gene G protein-coupled receptor 62 Neighboring gene poly (ADP-ribose) polymerase family, member 3 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene IQ motif containing F1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Scoumanne A, et al. Nucleic Acids Res, 2011 Jan. PMID 20817677, Free PMC Article
    2. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, et al. Trends Biochem Sci, 2016 Mar. PMID 26725301, Free PMC Article
    3. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, et al. Biochim Biophys Acta, 2015 May. PMID 25661197
    4. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    poly(rC)-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191883.1 → NP_001178812.1  poly(rC)-binding protein 4

      See identical proteins and their annotated locations for NP_001178812.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZYH1, D3ZCS3
      Related
      ENSRNOP00000017139.4, ENSRNOT00000017139.7
      Conserved Domains (3) summary
      cd22517
      Location:17 → 86
      KH-I_PCBP4_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins
      cd22520
      Location:101 → 172
      KH-I_PCBP4_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins
      cd22523
      Location:241 → 308
      KH-I_PCBP4_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115971751..115981987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265818.1 → XP_063121888.1  poly(rC)-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A961

    2. XM_006243803.5 → XP_006243865.1  poly(rC)-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A961
      Related
      ENSRNOP00000086533.1
      Conserved Domains (1) summary
      cl00098
      Location:101 → 172
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein Strain
    Heading Accession and Version

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