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    KGD4 alpha-ketoglutarate dehydrogenase subunit KGD4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850610, updated on 9-Jun-2024

    Summary

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    Gene symbol
    KGD4
    Gene description
    alpha-ketoglutarate dehydrogenase subunit KGD4
    Primary source
    FungiDB:YFR049W
    Locus tag
    YFR049W
    See related
    SGD:S000001945; AllianceGenome:SGD:S000001945; VEuPathDB:YFR049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YMR31
    Summary
    A structural constituent of ribosome. Contributes to oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Located in mitochondrial ribosome. Part of mitochondrial oxoglutarate dehydrogenase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KGD4 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (248523..248894)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene nicotinate-nucleotide diphosphorylase (carboxylating) Neighboring gene Rmd8p Neighboring gene proteasome core particle subunit beta 7 Neighboring gene coatomer subunit delta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative Translation Initiation at a UUG Codon Gives Rise to Two Functional Variants of the Mitochondrial Protein Kgd4. Heublein M, et al. J Mol Biol, 2019 Mar 29. PMID 30822412
    2. Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae. Eki T, et al. Yeast, 1996 Feb. PMID 8686379
    3. Cloning and analysis of the nuclear genes for two mitochondrial ribosomal proteins in yeast. Matsushita Y, et al. Mol Gen Genet, 1989 Oct. PMID 2693936
    4. The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165143, Free PMC Article
    5. N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae. Aksnes H, et al. PLoS One, 2013. PMID 23613772, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kgd4 is necessary for a stable incorporation of the E3 subunit into the E1-E2 core of yeast mitochondrial alpha-ketoglutarate dehydrogenase.
      Title: The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 2-oxoglutarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 2-oxoglutarate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-ketoglutarate dehydrogenase subunit KGD4
    NP_116707.3
    • Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; exists in two forms derived from a single mRNA translated from two alternative start sites; evolutionarily conserved role in the organization of mitochondrial alpha-KGDH complexes; homolog of human KGD4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      248523..248894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180014.3 → NP_116707.3  TPA: alpha-ketoglutarate dehydrogenase subunit KGD4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116707.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTT2, P19955
      UniProtKB/TrEMBL
      A0A6A5PXW3, A7A289, B3LUR0, C7GYF2, C8Z7Y4, G2WDJ0, N1P4S4
      Conserved Domains (1) summary
      pfam10937
      Location:16 → 122
      S36_mt; Ribosomal protein S36, mitochondrial
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19955.1

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