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    POM33 nucleoporin POM33 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850637, updated on 9-Jun-2024

    Summary

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    Gene symbol
    POM33
    Gene description
    nucleoporin POM33
    Primary source
    FungiDB:YLL023C
    Locus tag
    YLL023C
    See related
    SGD:S000003946; AllianceGenome:SGD:S000003946; VEuPathDB:YLL023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nuclear pore localization and nuclear pore organization. Located in endoplasmic reticulum and nuclear envelope. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See POM33 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (97997..98836, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU17 Neighboring gene Hsp70 family chaperone SSA2 Neighboring gene Hif1p Neighboring gene Spa2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
    2. The sequence of 32b on the left arm of yeast chromosome XII reveals six known genes, a new member of the seripauperins family and a new ABS transporter homologous to the human multidrug resistance protein. Purnelle B, et al. Yeast, 1997 Feb. PMID 9046100
    3. Distribution of Proteins at the Inner Nuclear Membrane Is Regulated by the Asi1 E3 Ligase in Saccharomyces cerevisiae. Smoyer CJ, et al. Genetics, 2019 Apr. PMID 30709848, Free PMC Article
    4. Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. Zhang W, et al. J Cell Biol, 2018 Mar 5. PMID 29439116, Free PMC Article
    5. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Casey AK, et al. Mol Biol Cell, 2015 Aug 1. PMID 26041935, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin POM33
    NP_013077.1
    • Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      97997..98836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181843.1 → NP_013077.1  TPA: nucleoporin POM33 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXY1, Q12164
      UniProtKB/TrEMBL
      A0A8H4BZ88, A7A0N4, B5VMS3, N1NYK9
      Conserved Domains (1) summary
      pfam03661
      Location:19 → 264
      UPF0121; Uncharacterized protein family (UPF0121)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12164.1

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