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    rnm RNase AM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945857, updated on 6-Jun-2024

    Summary

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    Gene symbol
    rnm
    Gene description
    RNase AM
    Primary source
    ASAP:ABE-0004252
    Locus tag
    b1266
    See related
    ECOCYC:G6634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1260; trpH; yciV
    Summary
    YciV is a PHP (Polymerase and Histidinol Phosphatase) domain protein, possibly encoding a metal-dependent phosphoesterase of unknown function. [More information is available at EcoGene: EG14257].
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    Genomic context

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    Sequence:
    NC_000913.3 (1323220..1324101)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene anthranilate synthase subunit TrpD Neighboring gene anthranilate synthase subunit TrpE Neighboring gene trp operon leader peptide Neighboring gene putative RNA-binding protein YciO Neighboring gene DUF2207 domain-containing protein YciQ Neighboring gene 23S rRNA pseudouridine(2605) synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli. Khodursky AB, et al. Proc Natl Acad Sci U S A, 2000 Oct 24. PMID 11027315, Free PMC Article
    2. Multiple feedback loops are key to a robust dynamic performance of tryptophan regulation in Escherichia coli. Venkatesh KV, et al. FEBS Lett, 2004 Apr 9. PMID 15063755
    3. Discovery of a Previously Unrecognized Ribonuclease from Escherichia coli That Hydrolyzes 5'-Phosphorylated Fragments of RNA. Ghodge SV, et al. Biochemistry, 2015 May 12. PMID 25871919
    4. RNase AM, a 5' to 3' exonuclease, matures the 5' end of all three ribosomal RNAs in E. coli. Jain C. Nucleic Acids Res, 2020 Jun 4. PMID 32343306, Free PMC Article
    5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TrpH is the first enzyme from E. coli that has been found to possess 5' --> 3' exoribonuclease activity
      Title: Discovery of a Previously Unrecognized Ribonuclease from Escherichia coli That Hydrolyzes 5'-Phosphorylated Fragments of RNA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3',5'-nucleotide bisphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within maturation of 5S rRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maturation of 5S rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maturation of LSU-rRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maturation of SSU-rRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNase AM
    NP_415782.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1323220..1324101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415782.1 RNase AM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415782.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6TQC6, A0A7A7B1L9, A0A8I0CEB4
      Conserved Domains (1) summary
      COG0613
      Location:7 → 269
      YciV; Predicted metal-dependent phosphoesterase TrpH, contains PHP domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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