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    rluB 23S rRNA pseudouridine(2605) synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945840, updated on 6-Jun-2024

    Summary

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    Gene symbol
    rluB
    Gene description
    23S rRNA pseudouridine(2605) synthase
    Primary source
    ASAP:ABE-0004259
    Locus tag
    b1269
    See related
    ECOCYC:EG12433
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1263; yciL
    Summary
    Ribosome-associated protein (Jiang, 2007). [More information is available at EcoGene: EG12433]. RluB is the pseudouridine synthase that catalyzes formation of pseudouridine at position 2605 in 23S rRNA. [More information is available at EcoCyc: EG12433].
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    Genomic context

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    Sequence:
    NC_000913.3 (1326852..1327727)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNase AM Neighboring gene putative RNA-binding protein YciO Neighboring gene DUF2207 domain-containing protein YciQ Neighboring gene cobinamide/cobalamin adenosyltransferase Neighboring gene putative oxidoreductase Neighboring gene S49 peptidase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation. Lundrigan MD, et al. J Bacteriol, 1989 Jan. PMID 2644187, Free PMC Article
    2. An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors. Toh SM, et al. J Mol Biol, 2008 Jul 18. PMID 18554609, Free PMC Article
    3. Four newly located pseudouridylate residues in Escherichia coli 23S ribosomal RNA are all at the peptidyltransferase center: analysis by the application of a new sequencing technique. Bakin A, et al. Biochemistry, 1993 Sep 21. PMID 8373778
    4. Phenotypic screening of Escherichia coli K-12 Tn5 insertion libraries, using whole-genome oligonucleotide microarrays. Winterberg KM, et al. Appl Environ Microbiol, 2005 Jan. PMID 15640221, Free PMC Article
    5. Intrinsic and extrinsic approaches for detecting genes in a bacterial genome. Borodovsky M, et al. Nucleic Acids Res, 1994 Nov 11. PMID 7984428, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 23S rRNA pseudouridine(2605) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA pseudouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enzyme-directed rRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enzyme-directed rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    23S rRNA pseudouridine(2605) synthase
    NP_415785.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1326852..1327727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415785.1 23S rRNA pseudouridine(2605) synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415785.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7PU83
      Conserved Domains (1) summary
      PRK10700
      Location:1 → 289
      PRK10700; 23S rRNA pseudouridine(2605) synthase RluB
    Nucleotide Protein
    Heading Accession and Version

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