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    btuR cobinamide/cobalamin adenosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945839, updated on 6-Jun-2024

    Summary

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    Gene symbol
    btuR
    Gene description
    cobinamide/cobalamin adenosyltransferase
    Primary source
    ASAP:ABE-0004261
    Locus tag
    b1270
    See related
    ECOCYC:EG10130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cobA; ECK1264
    Summary
    Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . [More information is available at EcoCyc: EG10130].
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    Genomic context

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    Sequence:
    NC_000913.3 (1327767..1328357, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2207 domain-containing protein YciQ Neighboring gene 23S rRNA pseudouridine(2605) synthase Neighboring gene putative oxidoreductase Neighboring gene S49 peptidase family protein Neighboring gene protein YciN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing and overexpression of cobA which encodes ATP:corrinoid adenosyltransferase in Salmonella typhimurium. Suh SJ, et al. Gene, 1993 Jul 15. PMID 7916712
    2. Separate regulatory systems for the repression of metE and btuB by vitamin B12 in Escherichia coli. Lundrigan MD, et al. Mol Gen Genet, 1987 Mar. PMID 3108627
    3. cobA function is required for both de novo cobalamin biosynthesis and assimilation of exogenous corrinoids in Salmonella typhimurium. Escalante-Semerena JC, et al. J Bacteriol, 1990 Jan. PMID 2403541, Free PMC Article
    4. Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation. Lundrigan MD, et al. J Bacteriol, 1989 Jan. PMID 2644187, Free PMC Article
    5. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables corrinoid adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables corrinoid adenosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerobic cobalamin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cobalamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cobalamin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cobinamide/cobalamin adenosyltransferase
    NP_415786.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1327767..1328357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415786.1 cobinamide/cobalamin adenosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415786.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QC73
      Conserved Domains (1) summary
      PRK05986
      Location:7 → 196
      PRK05986; cob(I)yrinic acid a,c-diamide adenosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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