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    ribA GTP cyclohydrolase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945763, updated on 6-Jun-2024

    Summary

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    Gene symbol
    ribA
    Gene description
    GTP cyclohydrolase 2
    Primary source
    ASAP:ABE-0004285
    Locus tag
    b1277
    See related
    ECOCYC:EG11331
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1272
    Summary
    GTP cyclohydrolase II catalyzes the opening of the imidazole ring of GTP and removal of pyrophosphate, the first committed step in riboflavin biosynthesis. [More information is available at EcoCyc: EG11331].
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    Genomic context

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    Sequence:
    NC_000913.3 (1338570..1339160, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YmiC Neighboring gene aconitate hydratase 1 Neighboring gene phosphatidylglycerophosphatase B Neighboring gene lipopolysaccharide assembly protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of vitamin B2. Kaiser J, et al. Eur J Biochem, 2002 Nov. PMID 12392559
    2. Biosynthesis of riboflavin. Single turnover kinetic analysis of GTP cyclohydrolase II. Schramek N, et al. J Biol Chem, 2001 Nov 23. PMID 11553632
    3. Regulation of the ribA gene encoding GTP cyclohydrolase II by the soxRS locus in Escherichia coli. Koh YS, et al. Mol Gen Genet, 1996 Jul 19. PMID 8709966
    4. Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli. Richter G, et al. J Bacteriol, 1993 Jul. PMID 8320220, Free PMC Article
    5. Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli. Foor F, et al. J Biol Chem, 1975 May 10. PMID 235552

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP cyclohydrolase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP cyclohydrolase II activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP cyclohydrolase II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP cyclohydrolase 2
    NP_415793.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1338570..1339160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415793.1 GTP cyclohydrolase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415793.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GIR8
      Conserved Domains (1) summary
      PRK00393
      Location:1 → 196
      ribA; GTP cyclohydrolase II RibA
    Nucleotide Protein
    Heading Accession and Version

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