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    pdxA 4-hydroxythreonine-4-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944919, updated on 6-Jun-2024

    Summary

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    Gene symbol
    pdxA
    Gene description
    4-hydroxythreonine-4-phosphate dehydrogenase
    Primary source
    ASAP:ABE-0000178
    Locus tag
    b0052
    See related
    ECOCYC:EG10691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0053
    Summary
    Converts 4-hydroxy-L-threonine phosphate (HTP) to 3-amino-2-oxopropyl phosphate. [More information is available at EcoGene: EG10691]. The crystal structure of PdxA has been solved at 1.96 A resolution. [More information is available at EcoCyc: EG10691].
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    Genomic context

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    Sequence:
    NC_000913.3 (52427..53416, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene diadenosine tetraphosphatase Neighboring gene DUF525 domain-containing protein ApaG Neighboring gene 16S rRNA m(6)2A1518,m(6)2A1519 dimethyltransferase Neighboring gene chaperone SurA Neighboring gene lipopolysaccharide assembly protein LptD Neighboring gene co-chaperone protein DjlA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. Banks J, et al. Bioorg Med Chem Lett, 2004 Apr 5. PMID 15026039
    2. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. Man TK, et al. J Bacteriol, 1996 Apr. PMID 8636054, Free PMC Article
    3. Genetic organization and restriction enzyme cleavage map of the ksgA-pdxA region of the Escherichia coli chromosome. Andrésson OS, et al. Mol Gen Genet, 1980. PMID 6256606
    4. Recent progress of vitamin B6 biosynthesis. Sakai A, et al. J Nutr Sci Vitaminol (Tokyo), 2004 Apr. PMID 15242009
    5. Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis. Drewke C, et al. FEBS Lett, 1993 Mar 1. PMID 8440369

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-hydroxythreonine-4-phosphate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxythreonine-4-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-hydroxythreonine-4-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxal phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyridoxine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridoxine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxythreonine-4-phosphate dehydrogenase
    NP_414594.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      52427..53416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414594.1 4-hydroxythreonine-4-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414594.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCN9
      Conserved Domains (1) summary
      PRK00232
      Location:1 → 329
      pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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