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    trpC fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945519, updated on 6-Jun-2024

    Summary

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    Gene symbol
    trpC
    Gene description
    fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
    Primary source
    ASAP:ABE-0004238
    Locus tag
    b1262
    See related
    ECOCYC:EG11026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1256; trpCF; trpF
    Summary
    The N-terminal synthase is the TrpC domain and the C-terminal isomerase domain is the TrpF domain. [More information is available at EcoGene: EG11026]. Bifunctional phosphoribosylanthranilate isomerase / indole-3-glycerol phosphate synthase (TrpC) carries out the third and fourth steps in the tryptophan biosynthesis pathway. [More information is available at EcoCyc: EG11026].
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    Genomic context

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    Sequence:
    NC_000913.3 (1318427..1319788, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stress-induced bacterial acidophilic repeat motifs-containing protein YciG Neighboring gene tryptophan synthase subunit alpha Neighboring gene tryptophan synthase subunit beta Neighboring gene anthranilate synthase subunit TrpD Neighboring gene anthranilate synthase subunit TrpE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Betaalpha-hairpin clamps brace betaalphabeta modules and can make substantive contributions to the stability of TIM barrel proteins. Yang X, et al. PLoS One, 2009 Sep 29. PMID 19787060, Free PMC Article
    2. Experimental evidence for the existence of a stable half-barrel subdomain in the (beta/alpha)8-barrel fold. Akanuma S, et al. J Mol Biol, 2008 Oct 3. PMID 18674541
    3. A detailed unfolding pathway of a (beta/alpha)8-barrel protein as studied by molecular dynamics simulations. Akanuma S, et al. Proteins, 2005 Feb 15. PMID 15614829
    4. 1-(o-Carboxyphenylamino)-1-deoxyribulose 5-phosphate, a new intermediate in the biosynthesis of tryptophan. SMITH OH, et al. J Biol Chem, 1960 Jul. PMID 13832114
    5. Evidence for the enzymatic synthesis of N-(5'-phosphoribosyl) anthranilic acid, a new intermediate in tryptophan biosynthesis. DOY CH, et al. Biochem Biophys Res Commun, 1961 Jan 25. PMID 13724174

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the unfolding pathway of ePRAI, a (beta/alpha)8-barrel protein, by molecular dynamics simulations
      Title: A detailed unfolding pathway of a (beta/alpha)8-barrel protein as studied by molecular dynamics simulations.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables indole-3-glycerol-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables indole-3-glycerol-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables indole-3-glycerol-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylanthranilate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tryptophan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
    NP_415778.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1318427..1319788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415778.3 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415778.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X5H0P3, A0AAE9TQE7, Q2XN48
      Conserved Domains (1) summary
      PRK09427
      Location:1 → 453
      PRK09427; bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials