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    trpL trp operon leader peptide [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945856, updated on 2-May-2024

    Summary

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    Gene symbol
    trpL
    Gene description
    trp operon leader peptide
    Primary source
    ASAP:ABE-0004246
    Locus tag
    b1265
    See related
    ECOCYC:EG11274
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1259; trpEE
    Summary
    The TrpL leader peptide is a key component in the attenuation system that controls expression of the trpLEDCBA operon in response to tryptophan availability . trpL occurs within a 130-nucleotide region at the beginning of the trp operon . [More information is available at EcoCyc: EG11274].
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    Genomic context

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    Sequence:
    NC_000913.3 (1323038..1323082, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene anthranilate synthase subunit TrpD Neighboring gene anthranilate synthase subunit TrpE Neighboring gene RNase AM Neighboring gene putative RNA-binding protein YciO Neighboring gene DUF2207 domain-containing protein YciQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis. Yanofsky C. Trends Genet, 2004 Aug. PMID 15262409
    2. Transcription attenuation: once viewed as a novel regulatory strategy. Yanofsky C. J Bacteriol, 2000 Jan. PMID 10613855, Free PMC Article
    3. Effects of DNA base analogs on transcription termination at the tryptophan operon attenuator of EScherichia coli. Farnham PJ, et al. Proc Natl Acad Sci U S A, 1982 Feb. PMID 7041118, Free PMC Article
    4. Stability of an RNA secondary structure affects in vitro transcription pausing in the trp operon leader region. Landick R, et al. J Biol Chem, 1984 Sep 25. PMID 6206069
    5. Translation activates the paused transcription complex and restores transcription of the trp operon leader region. Landick R, et al. Proc Natl Acad Sci U S A, 1985 Jul. PMID 2991886, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of tryptophan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trp operon leader peptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1323038..1323082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415781.1 trp operon leader peptide [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415781.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0AD92
    Nucleotide Protein
    Heading Accession and Version

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