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    pyrD dihydroorotate dehydrogenase, type 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945556, updated on 2-May-2024

    Summary

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    Gene symbol
    pyrD
    Gene description
    dihydroorotate dehydrogenase, type 2
    Primary source
    ASAP:ABE-0003201
    Locus tag
    b0945
    See related
    ECOCYC:EG10807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0936
    Summary
    The enzyme is a membrane-bound flavoprotein. [More information is available at EcoCyc: EG10807].
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    Genomic context

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    Sequence:
    NC_000913.3 (1004768..1005778)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbU Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene cell division protein ZapC Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Kow RL, et al. Biochemistry, 2009 Oct 20. PMID 19694481, Free PMC Article
    2. Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Fagan RL, et al. Biochemistry, 2009 Aug 4. PMID 19530672, Free PMC Article
    3. Defects in vesicle core induced by escherichia coli dihydroorotate dehydrogenase. Couto SG, et al. Biophys J, 2008 Mar 1. PMID 17993483, Free PMC Article
    4. Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. Fagan RL, et al. Biochemistry, 2006 Dec 19. PMID 17154530
    5. Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics. Shi J, et al. J Am Chem Soc, 2004 Jun 9. PMID 15174861

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition.
      Title: New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of the pyrD gene of Escherichia coli and characterization of the flavoprotein dihydroorotate dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroorotate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroorotate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydroorotate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroorotate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine ribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dihydroorotate dehydrogenase, type 2
    NP_415465.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1004768..1005778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415465.1 dihydroorotate dehydrogenase, type 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415465.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A827Y4C7
      Conserved Domains (1) summary
      PRK05286
      Location:1 → 336
      PRK05286; quinone-dependent dihydroorotate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials