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    ycbX 6-N-hydroxylaminopurine resistance protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945563, updated on 2-May-2024

    Summary

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    Gene symbol
    ycbX
    Gene description
    6-N-hydroxylaminopurine resistance protein
    Primary source
    ASAP:ABE-0003206
    Locus tag
    b0947
    See related
    ECOCYC:G6487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0938
    Summary
    Molybdenum cofactor (MoCo), YcbX and YiiM are involved in the detoxification of 6-N-hydroxylaminopurine (HAP), which proceeds by a reduction to adenine (Kozmin, 2008). [More information is available at EcoGene: EG13716]. YcbX functions in the molybdenum cofactor-dependent pathway for detoxification of N-hydroxylated base analogs . [More information is available at EcoCyc: G6487].
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    Genomic context

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    Sequence:
    NC_000913.3 (1006491..1007600, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene dihydroorotate dehydrogenase, type 2 Neighboring gene cell division protein ZapC Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase Neighboring gene ATP-binding protein Uup

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes. Zhai Y, et al. Protein Sci, 2002 Sep. PMID 12192075, Free PMC Article
    2. YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues. Kozmin SG, et al. Mol Microbiol, 2008 Apr. PMID 18312271, Free PMC Article
    3. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043
    4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
    5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within toxin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-N-hydroxylaminopurine resistance protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1006491..1007600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415467.1 6-N-hydroxylaminopurine resistance protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415467.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6L7CCJ6
      Conserved Domains (2) summary
      COG0633
      Location:288 → 367
      Fdx; Ferredoxin [Energy production and conversion]
      COG3217
      Location:1 → 271
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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