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    Stk19 serine/threonine kinase 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361800, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stk19provided by RGD
    Official Full Name
    serine/threonine kinase 19provided by RGD
    Primary source
    RGD:1359601
    See related
    Ensembl:ENSRNOG00000048929 AllianceGenome:RGD:1359601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and small GTPase binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and protein phosphorylation. Predicted to be located in nuclear speck. Orthologous to human STK19 (serine/threonine kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 89.4), Lung (RPKM 37.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stk19 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4000216..4009743)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3995590..4005117)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4317440..4517128, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SKI2 subunit of superkiller complex Neighboring gene decapping exoribonuclease Neighboring gene complement C4A Neighboring gene cytochrome P450, family 21, subfamily a, polypeptide 1 Neighboring gene tenascin XA, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase. Gomez-Escobar N, et al. J Biol Chem, 1998 Nov 20. PMID 9812991
    2. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, et al. Cell, 2019 Feb 21. PMID 30712867
    3. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Walter L, et al. Immunogenetics, 2002 Jul. PMID 12136338
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine/threonine-protein kinase 19
    Names
    serine/threonine-protein kinase 19
    NP_001013215.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013197.2 → NP_001013215.2  inactive serine/threonine-protein kinase 19

      Status: VALIDATED

      Source sequence(s)
      BC061571, CO398403
      UniProtKB/TrEMBL
      A0A8I5ZJ96, Q6P7Q3
      Related
      ENSRNOP00000076734.1, ENSRNOT00000072446.4
      Conserved Domains (1) summary
      pfam10494
      Location:28 → 251
      Stk19; Serine-threonine protein kinase 19

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4000216..4009743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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