Sgcb sarcoglycan, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sgcbprovided by RGD
Official Full Name: sarcoglycan, betaprovided by RGD
Primary source: RGD:1594202
See related: Ensembl:ENSRNOG00000002135 AllianceGenome:RGD:1594202
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in muscle organ development. Predicted to act upstream of or within cardiac muscle cell development and vascular associated smooth muscle cell development. Predicted to be located in plasma membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E and muscular dystrophy. Orthologous to human SGCB (sarcoglycan beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 513.6), Heart (RPKM 493.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (34917663..34932661)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (34563614..34578614)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (37113194..37128623)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cerebellar neurons and glial cells alpha-, beta-, gamma-, delta-, and epsilon-sarcoglycans are all expressed.
Title: Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134435 (e-PCR)
- UniSTS:217715

RH132678 (e-PCR)
- UniSTS:215961

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dystroglycan complex	ISO Inferred from Sequence Orthology more info
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of sarcoglycan complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sarcoglycan complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-sarcoglycan

Names: sarcoglycan, beta (dystrophin-associated glycoprotein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.