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    Bmcp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39322, updated on 10-May-2024

    Summary

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    Official Symbol
    Bmcpprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036199
    Locus tag
    Dmel_CG7314
    See related
    AllianceGenome:FB:FBgn0036199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bmcp; BMCP; CG7314; DmBMCP; Dmel\CG7314; dmUcp5; dmUCP5; DmUCP5; dUCP5; ucp5; Ucp5; UCP5
    Summary
    Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Involved in regulation of metabolic process and sensory perception of sound. Is expressed in Johnston organ; adult head; adult heart; and organism. Orthologous to human SLC25A14 (solute carrier family 25 member 14) and SLC25A30 (solute carrier family 25 member 30). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Bmcp in Genome Data Viewer
    Location:
    68D3-68D3; 3-36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11720934..11728118)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11714034..11721218)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain containing 56 Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene uncharacterized protein Neighboring gene crimpled Neighboring gene sisters unbound Neighboring gene uncharacterized protein Neighboring gene lost and found

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of Drosophila uncoupling protein 5 in metabolism and aging. Sánchez-Blanco A, et al. Genetics, 2006 Mar. PMID 16387864, Free PMC Article
    2. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. Da-Ré C, et al. EMBO Rep, 2014 May. PMID 24639557, Free PMC Article
    3. Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease. Besson MT, et al. Hum Mol Genet, 2010 Sep 1. PMID 20566711
    4. Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein. Hanák P, et al. FEBS Lett, 2001 Apr 27. PMID 11334880
    5. The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease. Rosas-Arellano A, et al. Int J Mol Sci, 2018 Aug 14. PMID 30110961, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 11723163-11727872 mobile_element_type = transposon:Doc{}984

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bmcp
    Names
    Bmcp-PA
    Bmcp-PB
    CG7314-PA
    CG7314-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11720934..11728118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140244.5 → NP_648501.1  bmcp, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K566
      Related
      FBpp0075846
      Conserved Domains (1) summary
      pfam00153
      Location:7 → 97
      Mito_carr; Mitochondrial carrier protein

    2. NM_168472.2 → NP_729738.1  bmcp, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K566
      Related
      FBpp0075845
      Conserved Domains (1) summary
      pfam00153
      Location:7 → 97
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K566.1 Q7K566

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