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    CG3216 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37376, updated on 19-Jun-2024

    Summary

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    Official Symbol
    CG3216provided by FlyBase
    Primary source
    FLYBASE:FBgn0034568
    Locus tag
    Dmel_CG3216
    See related
    AllianceGenome:FB:FBgn0034568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3216; GYC
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG3216 in Genome Data Viewer
    Location:
    57B5-57B5; 2-92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20986833..20991171, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16874338..16878676, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dim gamma-tubulin 3 Neighboring gene Proteasome alpha3 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
    2. The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Overend G, et al. Peptides, 2012 Mar. PMID 21893139
    3. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
    4. cGMP signaling pathway that modulates NF-κB activation in innate immune responses. Kanoh H, et al. iScience, 2021 Dec 17. PMID 34988396, Free PMC Article
    5. Drosophila, an emerging model for cardiac disease. Bier E, et al. Gene, 2004 Nov 10. PMID 15527959

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3216-PC
    CG3216-PD
    NP_611532.2
    NP_726013.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20986833..20991171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137688.2 → NP_611532.2  uncharacterized protein Dmel_CG3216, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611532.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2P1
      Conserved Domains (7) summary
      cd06373
      Location:90 → 498
      PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family
      smart00219
      Location:562 → 812
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:853 → 1044
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:880 → 1066
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:107 → 479
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:817 → 874
      HNOBA; Heme NO binding associated
      cl21453
      Location:551 → 820
      PKc_like; Protein Kinases, catalytic domain

    2. NM_166415.2 → NP_726013.2  uncharacterized protein Dmel_CG3216, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726013.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLX0
      Conserved Domains (7) summary
      cd06373
      Location:90 → 496
      PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family
      smart00219
      Location:627 → 877
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:918 → 1109
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:945 → 1131
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:107 → 479
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:882 → 939
      HNOBA; Heme NO binding associated
      cl21453
      Location:616 → 885
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLX0 Q8MLX0
    Q9W2P1 Q9W2P1

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