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    Rev1 REV1, DNA directed polymerase [ Mus musculus (house mouse) ]

    Gene ID: 56210, updated on 22-May-2024

    Summary

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    Official Symbol
    Rev1provided by MGI
    Official Full Name
    REV1, DNA directed polymeraseprovided by MGI
    Primary source
    MGI:MGI:1929074
    See related
    Ensembl:ENSMUSG00000026082 AllianceGenome:MGI:1929074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rev1l; 1110027I23Rik
    Summary
    Enables deoxycytidyl transferase activity. Acts upstream of or within error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.2), CNS E14 (RPKM 7.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rev1 in Genome Data Viewer
    Location:
    1 B; 1 16.46 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38091867..38169191, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38052786..38129921, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_00689 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene predicted gene, 34448 Neighboring gene STARR-seq mESC enhancer starr_00690 Neighboring gene STARR-seq mESC enhancer starr_00691 Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females. In Het Panhuis W, et al. Am J Physiol Endocrinol Metab, 2022 Mar 1. PMID 35156394
    2. Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity. Prasad R, et al. Nucleic Acids Res, 2016 Dec 15. PMID 27683219, Free PMC Article
    3. Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells. Hashimoto K, et al. DNA Repair (Amst), 2016 Oct. PMID 27497692, Free PMC Article
    4. Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway. Krijger PH, et al. Eur J Immunol, 2013 Oct. PMID 23857323
    5. A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation. Masuda K, et al. J Immunol, 2009 Aug 1. PMID 19587019

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females.
      Title: Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females.
    2. Rev1 contributes to proper mitochondrial function via the PARP-NAD-SIRT1-PGC1A axis.
      Title: Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis.
    3. These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents.
      Title: Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.
    4. Rev1 could serve as a backup polymerase in base excision repair and could potentially contribute to activation-induced cytidine deaminase-initiated antibody diversification through this activity.
      Title: Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.
    5. The results support the idea that Rev1 is not essential for the cellular translesion DNA synthesis functions of DNA polymerase zeta in mammalian cells.
      Title: Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells.
    6. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
      Title: REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18.
    7. Rev1 is essential for the Msh2-independent generation of these transversions downstream of Ung2-induced apyrimidinic sites.
      Title: Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.
    8. Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1(-/-)Msh2(-/-) B cells.
      Title: Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.
    9. Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa
      Title: Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.
    10. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.
      Title: Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66950

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxycytidyl transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxycytidyl transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-free translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein REV1
    Names
    REV1 homolog
    rev1-like terminal deoxycytidyl transferase

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359287.1 → NP_001346216.1  DNA repair protein REV1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114583
      Conserved Domains (3) summary
      cd01701
      Location:16 → 333
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:666 → 759
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:516 → 551
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    2. NM_001359288.1 → NP_001346217.1  DNA repair protein REV1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114583
      Conserved Domains (3) summary
      cd12145
      Location:634 → 727
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:484 → 519
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
      cl28996
      Location:1 → 301
      PolY; Y-family of DNA polymerases

    3. NM_019570.4 → NP_062516.2  DNA repair protein REV1 isoform 1

      See identical proteins and their annotated locations for NP_062516.2

      Status: VALIDATED

      Source sequence(s)
      AK048838, BC058093
      Consensus CDS
      CCDS14899.1
      UniProtKB/Swiss-Prot
      Q920Q2, Q9QXV2
      Related
      ENSMUSP00000027251.7, ENSMUST00000027251.12
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1155 → 1248
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1005 → 1040
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      38091867..38169191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255641.2 → XP_030111501.1  DNA repair protein REV1 isoform X3

      Conserved Domains (4) summary
      cd01701
      Location:346 → 812
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1145 → 1238
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:995 → 1030
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    2. XM_036152478.1 → XP_036008371.1  DNA repair protein REV1 isoform X2

      Conserved Domains (4) summary
      cd01701
      Location:346 → 821
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1154 → 1247
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    3. XM_006496155.5 → XP_006496218.2  DNA repair protein REV1 isoform X3

      Conserved Domains (4) summary
      cd01701
      Location:346 → 812
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1145 → 1238
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:995 → 1030
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    4. XM_036152474.1 → XP_036008367.1  DNA repair protein REV1 isoform X5

      Conserved Domains (4) summary
      cd01701
      Location:346 → 779
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1112 → 1205
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:962 → 997
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    5. XM_006496154.5 → XP_006496217.2  DNA repair protein REV1 isoform X2

      Conserved Domains (4) summary
      cd01701
      Location:346 → 821
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1154 → 1247
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    6. XM_006496153.5 → XP_006496216.2  DNA repair protein REV1 isoform X1

      UniProtKB/Swiss-Prot
      Q920Q2, Q9QXV2
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1155 → 1248
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1005 → 1040
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    7. XM_036152475.1 → XP_036008368.1  DNA repair protein REV1 isoform X1

      UniProtKB/Swiss-Prot
      Q920Q2, Q9QXV2
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1155 → 1248
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1005 → 1040
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    8. XM_036152479.1 → XP_036008372.1  DNA repair protein REV1 isoform X2

      Conserved Domains (4) summary
      cd01701
      Location:346 → 821
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1154 → 1247
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1004 → 1039
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    9. XM_030255639.2 → XP_030111499.1  DNA repair protein REV1 isoform X1

      UniProtKB/Swiss-Prot
      Q920Q2, Q9QXV2
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1155 → 1248
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1005 → 1040
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    10. XM_006496156.4 → XP_006496219.1  DNA repair protein REV1 isoform X4

      Conserved Domains (4) summary
      cd01701
      Location:361 → 837
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1170 → 1263
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:63 → 146
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      pfam14377
      Location:948 → 969
      DUF4414; Domain of unknown function (DUF4414)

    11. XM_036152481.1 → XP_036008374.1  DNA repair protein REV1 isoform X7

      Conserved Domains (3) summary
      cd12145
      Location:634 → 727
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:484 → 519
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
      cl28996
      Location:1 → 301
      PolY; Y-family of DNA polymerases

    12. XM_036152477.1 → XP_036008370.1  DNA repair protein REV1 isoform X1

      UniProtKB/Swiss-Prot
      Q920Q2, Q9QXV2
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1155 → 1248
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1005 → 1040
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    13. XM_036152476.1 → XP_036008369.1  DNA repair protein REV1 isoform X1

      UniProtKB/Swiss-Prot
      Q920Q2, Q9QXV2
      Conserved Domains (4) summary
      cd01701
      Location:346 → 822
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:1155 → 1248
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48 → 131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
      cd19318
      Location:1005 → 1040
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    14. XM_006496161.3 → XP_006496224.1  DNA repair protein REV1 isoform X6

      Conserved Domains (3) summary
      cd01701
      Location:16 → 333
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:666 → 759
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:516 → 551
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    15. XM_017321835.2 → XP_017177324.1  DNA repair protein REV1 isoform X7

      Conserved Domains (3) summary
      cd12145
      Location:634 → 727
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:484 → 519
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
      cl28996
      Location:1 → 301
      PolY; Y-family of DNA polymerases

    16. XM_017321836.2 → XP_017177325.1  DNA repair protein REV1 isoform X6

      Conserved Domains (3) summary
      cd01701
      Location:16 → 333
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:666 → 759
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:516 → 551
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    17. XM_006496162.2 → XP_006496225.1  DNA repair protein REV1 isoform X7

      See identical proteins and their annotated locations for XP_006496225.1

      Conserved Domains (3) summary
      cd12145
      Location:634 → 727
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:484 → 519
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
      cl28996
      Location:1 → 301
      PolY; Y-family of DNA polymerases

    18. XM_036152480.1 → XP_036008373.1  DNA repair protein REV1 isoform X6

      Related
      ENSMUST00000194650.6
      Conserved Domains (3) summary
      cd01701
      Location:16 → 333
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:666 → 759
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:516 → 551
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    19. XM_036152482.1 → XP_036008375.1  DNA repair protein REV1 isoform X7

      Conserved Domains (3) summary
      cd12145
      Location:634 → 727
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd19318
      Location:484 → 519
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
      cl28996
      Location:1 → 301
      PolY; Y-family of DNA polymerases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920Q2.1 GenPept UniProtKB/Swiss-Prot:Q920Q2

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