Manf mesencephalic astrocyte-derived neurotrophic factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Manfprovided by MGI
Official Full Name: mesencephalic astrocyte-derived neurotrophic factorprovided by MGI
Primary source: MGI:MGI:1922090
See related: Ensembl:ENSMUSG00000032575 AllianceGenome:MGI:1922090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Armet; D18Mgi17; 3230402M22Rik
Summary: Predicted to enable sulfatide binding activity. Acts upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Predicted to be located in endoplasmic reticulum lumen and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 52.6), testis adult (RPKM 26.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.98 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106765952..106769137, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106888753..106891938, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-kappaB pathway.
Title: Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway.
Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen.
Title: Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen.
S100a16 Deficiency Prevents Alcohol-induced Fatty Liver Injury via Inducing MANF Expression in Mice.
Title: S100a16 Deficiency Prevents Alcohol-induced Fatty Liver Injury via Inducing MANF Expression in Mice.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Title: MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity.
Title: Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity.
MANF inhibits Sjogren's syndrome salivary gland epithelial cell apoptosis and antigen expression of Ro52/SSA through endoplasmic reticulum stress/autophagy pathway.
Title: MANF inhibits Sjögren's syndrome salivary gland epithelial cell apoptosis and antigen expression of Ro52/SSA through endoplasmic reticulum stress/autophagy pathway.
Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration.
Title: Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration.
The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity.
Title: The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity.
Mesencephalic astrocyte-derived neurotrophic factor restores blood-brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-kappaB pathway.
Title: Mesencephalic astrocyte-derived neurotrophic factor restores blood-brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-κB pathway.
Deficiency of mesencephalic astrocyte-derived neurotrophic factor affects neurogenesis in mouse brain.
Title: Deficiency of mesencephalic astrocyte-derived neurotrophic factor affects neurogenesis in mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125819 (e-PCR)
- UniSTS:162564

RH129214 (e-PCR)
- UniSTS:212522

D17914 (e-PCR)
- UniSTS:124739

RH124334 (e-PCR)
- UniSTS:161156

SGC32878 (e-PCR)
- UniSTS:38026

RH125717 (e-PCR)
- UniSTS:162480

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables sulfatide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mesencephalic astrocyte-derived neurotrophic factor

Names: arginine-rich protein; arginine-rich, mutated in early stage tumors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029103.4 → NP_083379.2 mesencephalic astrocyte-derived neurotrophic factor precursor

See identical proteins and their annotated locations for NP_083379.2

Status: VALIDATED

Source sequence(s)

AK131997

Consensus CDS

CCDS23486.1

UniProtKB/Swiss-Prot

Q3TMX5, Q9CXI5

UniProtKB/TrEMBL

A8C1V1

Related

ENSMUSP00000124562.2, ENSMUST00000159283.8

Conserved Domains (1) summary

pfam10208
Location:26 → 170

Armet; Degradation arginine-rich protein for mis-folding