Vti1b vesicle transport through interaction with t-SNAREs 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vti1bprovided by MGI
Official Full Name: vesicle transport through interaction with t-SNAREs 1Bprovided by MGI
Primary source: MGI:MGI:1855688
See related: Ensembl:ENSMUSG00000021124 AllianceGenome:MGI:1855688
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GES30; SNARE; MVti1b; Vti1-rp1
Summary: Predicted to enable SNAP receptor activity; SNARE binding activity; and chloride channel inhibitor activity. Predicted to be involved in several processes, including Golgi vesicle transport; regulation of protein localization to plasma membrane; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Located in Golgi apparatus and perinuclear region of cytoplasm. Is anchored component of membrane. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human VTI1B (vesicle transport through interaction with t-SNAREs 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 37.7), frontal lobe adult (RPKM 36.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 35.51 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (79202791..79219428, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (79156017..79172685, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
Title: Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
Title: Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
This studied demonstratedt that the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex.
Title: Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function.
Our data demonstrate that contrary to the accepted model, SEC22B is not necessary for cross-presentation, cautioning against extrapolating phenotypes from knockdown studies alone.
Title: A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.
This study reveals that the SNARE-dependent exocytosis in glial cells contributes to neurotoxicity during ischemia in vivo and suggests glial exocytosis as a target for therapeutic approaches.
Title: Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration.
syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes
Title: Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli.
The dnSNARE mice performed significantly better than littermate controls on rung walk and adhesive dot removal tasks following lesion. and demonistraed that the important role of astrocytic signaling under ischemic conditions.
Title: Inhibition of a SNARE-sensitive pathway in astrocytes attenuates damage following stroke.
These results suggest that SNARE proteins are necessary for the increased activity of KCC2 after Zn(2+) stimulation of mZnR/GPR39.
Title: SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.
Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages.
Title: Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages.
The identify IR as the first known tyrosine kinase for Munc18c as in GLUT4 vesicle exocytosis, exemplifying a new model for the coordination of SNARE assembly and vesicle mobilization events in response to a single extracellular stimulus.
Title: Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU015348 (e-PCR)
- UniSTS:208826

PMC165714P1 (e-PCR)
- UniSTS:271547

AU022422 (e-PCR)
- UniSTS:180412

RH141711 (e-PCR)
- UniSTS:223704

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info	PubMed
enables chloride channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicle transport through interaction with t-SNAREs homolog 1B

Names: A novel SNARE; Soluble N-ethylmaleimide-sensitive factor-attachment protein receptor; vesicle transport through interaction with t-SNAREs 1B homolog; vesicle transport v-SNARE protein Vti1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364374.1 → NP_001351303.1 vesicle transport through interaction with t-SNAREs homolog 1B isoform 2

Status: VALIDATED

Source sequence(s)

AC154585

UniProtKB/TrEMBL

Q3TUP8

Conserved Domains (2) summary

cd15890
Location:75 → 136

SNARE_Vti1b; SNARE motif of Vti1b-like

pfam05008
Location:1 → 35

V-SNARE; Vesicle transport v-SNARE protein N-terminus
NM_001422642.1 → NP_001409571.1 vesicle transport through interaction with t-SNAREs homolog 1B isoform 2

Status: VALIDATED

Source sequence(s)

AC154585
NM_016800.3 → NP_058080.2 vesicle transport through interaction with t-SNAREs homolog 1B isoform 1

See identical proteins and their annotated locations for NP_058080.2

Status: VALIDATED

Source sequence(s)

BQ177030, BY280269, CX239415

Consensus CDS

CCDS26008.1

UniProtKB/Swiss-Prot

O88384

UniProtKB/TrEMBL

Q91XH6

Related

ENSMUSP00000057462.7, ENSMUST00000055262.13

Conserved Domains (2) summary

cd15890
Location:136 → 197

SNARE_Vti1b; SNARE motif of Vti1b-like

pfam05008
Location:18 → 96

V-SNARE; Vesicle transport v-SNARE protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

79202791..79219428 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157529.1 → XP_036013422.1 vesicle transport through interaction with t-SNAREs homolog 1B isoform X1

UniProtKB/Swiss-Prot

O88384

Conserved Domains (2) summary

cd15890
Location:133 → 194

SNARE_Vti1b; SNARE motif of Vti1b-like

pfam05008
Location:36 → 93

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_036157530.1 → XP_036013423.1 vesicle transport through interaction with t-SNAREs homolog 1B isoform X3

Conserved Domains (1) summary

cd15890
Location:22 → 83

SNARE_Vti1b; SNARE motif of Vti1b-like