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    uvrC excinuclease ABC subunit UvrC [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886672, updated on 6-Oct-2023

    Summary

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    Gene symbol
    uvrC
    Gene description
    excinuclease ABC subunit UvrC
    Locus tag
    Rv1420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (1594042..1595982)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene lipoprotein LprH Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene transcriptional regulator WhiA Neighboring gene membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function. Thakur M, et al. FEBS J, 2021 Feb. PMID 32602194
    2. Homology modeling, molecular docking and DNA binding studies of nucleotide excision repair UvrC protein from M. tuberculosis. Parulekar RS, et al. Protein J, 2013 Aug. PMID 23963890
    3. The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action. Rossi F, et al. Nucleic Acids Res, 2011 Sep 1. PMID 21622956, Free PMC Article
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function.
      Title: The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function.
    2. Structural bioinformatics, homology modeling and molecular docking techniques were used to study UvrC protein from M. tuberculosis.
      Title: Homology modeling, molecular docking and DNA binding studies of nucleotide excision repair UvrC protein from M. tuberculosis.
    3. Data indicates a key functional role for UvrA in protection against reactive oxygen and nitrogen species-triggered DNA damage.
      Title: The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    excinuclease ABC subunit UvrC
    NP_215936.1
    • nuclease UvrC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1594042..1595982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215936.1 excinuclease ABC subunit UvrC [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215936.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M7Z2
      Conserved Domains (1) summary
      PRK00558
      Location:4 → 640
      uvrC; excinuclease ABC subunit UvrC
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WFC5.1

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